Blogs about: Bcr Abl
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Imatinib shows potential in pulmonary arterial hypertension (PAH)
Phase II data presented at the European Respiratory Society show Imatinib to demonstrate efficacy in the treatment of pulmonary arterial hypertension (PAH).… more →
Kinase News
Advances in Molecular Drug Development Highlighted
AACR Communications Staff wrote 1 month ago: PHILADELPHIA – The last decade has seen a major expansion in the cancer drug pipeline and stud … more →
AT-9283
kinasepro wrote 9 months ago: Astex’s unpartnered JAK/Aur/Abl Ph1b nib poster; clinic; PDB: 2W1G & 2W1I … more →
Imatinib shows potential in pulmonary arterial hypertension (PAH)
crimsoncanary wrote 1 year ago: Phase II data presented at the European Respiratory Society show Imatinib to demonstrate efficacy in … more →
Dasatinib effective in imatinib-resistant PDGFRA D842V mutant isoform
crimsoncanary wrote 1 year ago: In vitro data suggests that Dasatinib may be effective against imatinib-resistant GIST PDGFRA D842V … more →
Gleevec receives priority review in US for GIST after surgery
crimsoncanary wrote 1 year ago: Gleevec (imatinib) has been granted priority review status by the US Food and Drug Administration (F … more →
Imatinib in connective tissue diseases
crimsoncanary wrote 1 year ago: Three papers in this months Arthritis and Rheumatism discuss Imatinib in connective tissue diseases: … more →
Retrospective study shows imatinib treatment induces hypogammaglobulinemia
crimsoncanary wrote 1 year ago: A retrospective study of 72 chronic myeloid leukemia and 15 gastrointestinal stromal tumor patients … more →
Kinase Domain Mutation detection indicates risk of disease progression
crimsoncanary wrote 1 year ago: Researchers from Imperial College London have published data showing that screening of patients for … more →
SGX submit IND for Bcr-Abl inhibitor SGX393
crimsoncanary wrote 1 year ago: SGX Pharmaceuticals have submitted an IND to the FDA for Bcr-Abl inhibitor SGX393 or the treatment o … more →
Resistance to imatinib (Gleevec) caused by LYN kinase
crimsoncanary wrote 1 year ago: Data published in this weeks Journal of the National Cancer Institute shows that activation of LYN k … more →
Imatinib increases thrombolytic therapeutic window in stroke
crimsoncanary wrote 1 year ago: Researchers from the University of Michigan and the Karolinska Institute have found that imatinib (G … more →
Rhabdomyolysis - possible adverse effect of Imatinib
crimsoncanary wrote 1 year ago: In a letter to the New England Journal of Medicine French doctors have reported a case of severerhab … more →
Exelixis Bcr-Abl inhibitor shows efficacy in CML
crimsoncanary wrote 1 year ago: Phase I data presented at the European Hematology Association (EHA) meeting shows Exelixis’ Bc … more →
High initial dose of Gleevec results in better early responses in CML
crimsoncanary wrote 1 year ago: New phase III data shows that when Gleevec is administered at a high initial dose (800 mg/day) there … more →
Imatinib modulates synovial fibroblasts in arthritis model
crimsoncanary wrote 1 year ago: Data presented at EULAR shows that PDGFR kinase inhibitors can modulate synovial fibroblast activity … more →
Anti-fibrotic effect of Imatinib does not appear to affect vasculature
crimsoncanary wrote 1 year ago: Data presented at EULAR show Imatinib does not inhibit proliferation, migration or tube forming in e … more →
Phase III Dasatinib data demonstrates efficacy in Imatinib Resistant CML
crimsoncanary wrote 1 year ago: Phase III clinical data shows Dasatinib to demonstrate efficacy in chronic phase Imatinib Resistant … more →
Imatinib in C-Kit or PDGFR-β expressing metastatic breast cancer
crimsoncanary wrote 1 year ago: Imatinib mesylate was tested in patients with metastatic breast cancer expressing PDGFR or c-kit. No … more →
Imatinib in long term treatment of Chronic Myeloid Leukemia
crimsoncanary wrote 1 year ago: Researchers from Imperial College London have published data on long term (5 yr) treatment of Chroni … more →
