Blogs about: C Kit
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Imatinib shows potential in pulmonary arterial hypertension (PAH)
Phase II data presented at the European Respiratory Society show Imatinib to demonstrate efficacy in the treatment of pulmonary arterial hypertension (PAH).… more →
Kinase News
DAST (BAY 73-4506)
kinasepro wrote 7 months ago: It’s Bayer’s Ph2 follow-on to Sorafenib. VEGF / RAF yadda yadda… Don’t have … more →
Masitinib
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kinasepro wrote 7 months ago: aka: Masivet, Kinavet & AB-1010 quietly joined the Phase iii club when it went Ph3 back in Decem … more →
FDA Approves Use of Imatinib (Gleevec) for Adjuvant Therapy of Resected GIST
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bmirtsching wrote 10 months ago: On December 19, 2008, the FDA approved use of imatinib (Gleevec) for adjuvant therapy of resected ad … more →
Imatinib shows potential in pulmonary arterial hypertension (PAH)
crimsoncanary wrote 1 year ago: Phase II data presented at the European Respiratory Society show Imatinib to demonstrate efficacy in … more →
Pazopanib demonstrates efficacy in Sarcoma and Ovarian cancer
crimsoncanary wrote 1 year ago: Phase III data presented at the European of Medical Oncology (ESMO) show pazopanib to be effective i … more →
Amgen publish series of amido-benzisoxazole c-Kit inhibitors
crimsoncanary wrote 1 year ago: Amgen have published a series of c-Kit inhbitors … more →
Gleevec receives priority review in US for GIST after surgery
crimsoncanary wrote 1 year ago: Gleevec (imatinib) has been granted priority review status by the US Food and Drug Administration (F … more →
Imatinib & Docetaxel Produce Modest Response Against Recurrent Platinum Resistant/Refractory Ovarian Cancer
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Paul Cacciatore wrote 1 year ago: A combination of imatinib mesylate (Gleevec®) and docetaxel (Taxotere®) produced only a modest respo … more →
FDA grants SuperGen Orphan Drug Designation for MP-470 in Glioblastoma Multiforme
crimsoncanary wrote 1 year ago: SuperGen have announced that the U.S. FDA has granted orphan drug designation for the company’ … more →
Imatinib in connective tissue diseases
crimsoncanary wrote 1 year ago: Three papers in this months Arthritis and Rheumatism discuss Imatinib in connective tissue diseases: … more →
Amgen publish series of c-Kit inhibitors
crimsoncanary wrote 1 year ago: Amgen have published the discovery of amido-benzisoxazole c-Kit Inhibitor. … more →
Retrospective study shows imatinib treatment induces hypogammaglobulinemia
crimsoncanary wrote 1 year ago: A retrospective study of 72 chronic myeloid leukemia and 15 gastrointestinal stromal tumor patients … more →
Kinase Domain Mutation detection indicates risk of disease progression
crimsoncanary wrote 1 year ago: Researchers from Imperial College London have published data showing that screening of patients for … more →
Resistance to imatinib (Gleevec) caused by LYN kinase
crimsoncanary wrote 1 year ago: Data published in this weeks Journal of the National Cancer Institute shows that activation of LYN k … more →
Imatinib increases thrombolytic therapeutic window in stroke
crimsoncanary wrote 1 year ago: Researchers from the University of Michigan and the Karolinska Institute have found that imatinib (G … more →
Rhabdomyolysis - possible adverse effect of Imatinib
crimsoncanary wrote 1 year ago: In a letter to the New England Journal of Medicine French doctors have reported a case of severerhab … more →
High initial dose of Gleevec results in better early responses in CML
crimsoncanary wrote 1 year ago: New phase III data shows that when Gleevec is administered at a high initial dose (800 mg/day) there … more →
Imatinib modulates synovial fibroblasts in arthritis model
crimsoncanary wrote 1 year ago: Data presented at EULAR shows that PDGFR kinase inhibitors can modulate synovial fibroblast activity … more →
Anti-fibrotic effect of Imatinib does not appear to affect vasculature
crimsoncanary wrote 1 year ago: Data presented at EULAR show Imatinib does not inhibit proliferation, migration or tube forming in e … more →
