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Blogs about: Discoveries In Neuroscience

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DISCOVERIES IN NEUROSCIENCE September 2009

Cascade wrote 2 months ago: A STEP toward neuroprotection Excessive stimulation of NMDA receptors, important in the pathogenesis … more →

Tags: Alemtuzumab (Campath-1H), AURA, cAMP response element, CD4 T Cells, CD52, Cortical spreading depression (CSD), double blind crossover study, genetic biomarker, GVHD.

DISCOVERIES IN NEUROSCIENCE August 2009 Translating omics into drug discovery

Cascade wrote 3 months ago: The nanopeptide bradykinin is generated in stress conditions such as inflammation, trauma, burns, sh … more →

Tags: Allergy, Bdkrb1, Burns, CD3+ T, Cerebrospinal Fluid, chronic and acute inflammatory responses, cytosolic calcium, EAE CNS tissue, inflammation

Neural repolarization in schizophrenia

annalsofneurology wrote 6 months ago: Although evidence clearly indicates that genetic factors contribute to schizophrenia, it has been di … more →

Tags: antipsychotic drugs, dorsolateral prefrontal cortex, erg, ether-a-go-go (ERG) family potassium channel, fMRI, Gene, hippocampus, KCNH2, KCNH2-3.1 channels

Prostaglandin signaling promotes neuroinflamation

annalsofneurology wrote 6 months ago:   Opposite to previously reported results, Yao and colleagues demonstrate that prostaglandin E2 (PGE … more →

Tags: AutoImmune Disorders, Camp, candidate drug target, ep4, IL-23, Multiple Sclerosis, neuroinflamation, PGE2, pi3k

mTOR, oligodendrocyte differentiation and demyelinating disorders

annalsofneurology wrote 6 months ago: Although studies have identified multiple factors involved in oligodendrocyte fate commitment, littl … more →

Tags: Multiple Sclerosis, Remyelination, oligodendrocyte, mTOR, rapamycin, PI3K/Akt stimulation, mTORC1, mTORC2, white matter injury

Cell-surface glycosylation enables brain metastasis

annalsofneurology wrote 6 months ago:   Brain metastases in breast cancer patients tend to be a late event compared to other organs, sugge … more →

Tags: Blood Brain Barrier, brain metastases, breast cancer, estrogen-receptor, cyclooxigenase COX2, epidermal growth factor receptor, EGFR, HBEGF, A2

The resting immature brain is well connected

annalsofneurology wrote 6 months ago: Recent studies lend strong support for a default network that is active during passive or undirected … more →

Tags: fMRI, Autism, PEDIATRICS, posterior cingulate cortex/retrosplenial region, PCC/Rsp

Immunogenetics and narcolepsy

annalsofneurology wrote 6 months ago:   Narcolepsy with cataplexy is characterized by excessive sleepiness and rapid onset into REM sleep, … more →

Tags: narcolepsy, cataplexy, REM Sleep

A-beta secretases in traumatic brain injury

annalsofneurology wrote 6 months ago:   Traumatic brain injury (TBI) is a serious cause of morbidity and mortality especially among young … more →

Tags: Traumatic Brain Injury, TBI, Alzheimer’s disease, b-APP cleaving enzyme

Breaching the blood brain barrier

annalsofneurology wrote 6 months ago: Interleukin (IL)-17-producing CD4+ T cells (Th17) have been identified as a distinct subset of T hel … more →

Tags: experimental autoimmune encephalomyelitis, Interleukin 17–producing T helper cells, C-C chemokine receptor 6, CCR6, Blood Brain Barrier

Consideration of age in animal models

annalsofneurology wrote 7 months ago: Animal models are extremely useful for furthering our understanding of human disease pathophysiology … more →

Tags: Animal Models, human disease, therapeutic drug targets

Exciting consequences of genomic microdeletions

annalsofneurology wrote 7 months ago: Idiopathic generalized epilepsies (IGE) are among the most common forms of non-acquired seizure diso … more →

Tags: Idiopathic generalized epilepsies, CHRNA7, nicotinic acetylcholine receptor, candidate gene

Epigenetic regulation in the hippocampus, childhood abuse and suicide

annalsofneurology wrote 7 months ago: Early studies in rodents and nonhuman primates established a link between maternal care, the hypotha … more →

Tags: Abuse, Suicide, hippocampus, NR3C1, hippocampal glucocorticoid receptor expression

Training the brain to listen to its plasticity1 comment

annalsofneurology wrote 7 months ago: Previous studies have shown that adult musicians when compared with non-musicians have structural an … more →

Tags: ~Musician~, structural brain differences, MRI, right precentral gyrus, right primary auditory region

Fgfr1 is required for cortical regeneration and repair after perinatal hypoxia

annalsofneurology wrote 8 months ago: Hypoxia is a major cause of long term neurodevelopmental disabilities in prematurely born newborns.  … more →

Tags: Hypoxia, neurodevelopmental disabilities, prematurely born newborns, grey matter loss, FGF signaling, FGFR1

Dissecting the molecular pathways that underlie cerebral cavernous malformations

annalsofneurology wrote 8 months ago: Cerebral cavernous malformations (CCMs) are common and can cause serious morbidity and death if they … more →

Tags: Cerebral cavernous malformations, CCM, CCM1, CCM2, CCM3, HEG1, heart of glass receptor, KRIT1, simvastatin

Wither the lone investigator: the ascension of team science

annalsofneurology wrote 8 months ago: Although most modern-day scientists are aware of the extraordinary impact of the internet in enablin … more →

Tags: Collaborative research, multi-university collaborations, academic scientific research publication, authorship structure

Induced pluripotent stem cells to study the pathogenesis of inherited diseases

annalsofneurology wrote 8 months ago: Spinal muscular atrophy (SMA) is an autosomal recessive disorder caused by mutations in the survival … more →

Tags: spinal muscular atrophy, autosomal recessive disorder, survival motor neuron gene 1, SMN1, pluripotent stem cells

Candidate Schizophrenia Gene Blocks Myelin Inhibition of Axon Growth

annalsofneurology wrote 10 months ago: In schizophrenia, genetic predisposition has been linked to chromosome 22q11, and some myelin-specif … more →

Tags: chromosome 22q11, J Neurosci 2008;28:13161-72, myelin-specific genes, ngr, Nogo-66 receptor 1, RTN4R, schizophrenia


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