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protectores: y ademas engordan

rafabravo — Wed, 21 Oct 2009 07:18:06 +0000

y ademas de producir mono, encima engordan Long-term treatment with proton pump inhibitor is associa

Los inhibidores de la bomba de protones son los más efectivos en el tratamiento de la esofagitis

rafabravo — Sat, 17 Nov 2007 12:17:41 +0000

Pregunta Clínica: ¿Cual es el tratamiento más efectivo para la esofagitis por reflujo?

Respuesta: El tratamiento con inhibidores de la bomba de protones (IBPs) es el más eficaz para el manejo a corto plazo de la enfermedad por reflujo gastroesofágico (ERGE) – NNT= 1 a 2 (para IBPs vs placebo). Los IBPs fueron mejor que los anti-H2 y ambos superiores al placebo. Hay pocas pruebas sobre el tratamiento con procinéticos, y no hay pruebas de que sea superior al placebo

Contexto: ERGE es un problema común con una prevalencia estimada del 20% en adultos. Los IBPs y anti H2 mejoran los síntomas al reducir la secreción de acido en el estomago

Advertencia: En dosis equivalentes los diferentes IBPs no muestran diferencias estadísticamente significativas en las tasas de curación. Aunque hubo una aparente mayor tasa de persistencia de enfermedad al final del tratamiento con dosis doble de IBPs comparada con las dosis estándar, esta diferencia no fue estadísticamente significativa.

Referencia: Mostafizur Khan, Jose Santana, Clare Donnellan, Cathryn Preston, Paul Moayyedi. Medical treatments in the short term management of reflux oesophagitis. Cochrane Database of Systematic Reviews 2007, Issue 2. Art. No.: CD003244. DOI: 10.1002/14651858.CD003244.pub2.

Esta revision incluyo 134 ensayos con 35978 participantes.
Versión en español Mostafizur Khan, Jose Santana, Clare Donnellan, Cathryn Preston, Paul Moayyedi. Tratamientos médicos para el tratamiento a corto plazo de la esofagitis por reflujo (Revisión Cochrane traducida). En: La Biblioteca Cochrane Plus, 2007 Número 3. Oxford: Update Software Ltd. Disponible en: http://www.update-software.com. (Traducida de The Cochrane Library, 2007 Issue 3. Chichester, UK: John Wiley & Sons, Ltd.).

Perla Nº 19 Fecha: Mayo 2007, Autor: Brian R McAvoy. Trad: Rafael Bravo

NNT = número necesario a tratar para beneficiar a una persona.
NND = número necesario para dañar a una persona.
El NNT y el NND solamente son informados si los estudios o la combinación de ellos son estadísticamente significativos.

P.E.A.R.L.S: Inhibidores de la bomba de protones, mas efectivos en la esofagitis

Ruben Roa — Mon, 12 Nov 2007 16:47:00 +0000

Proton pump inhibitors (PPPIs) most effective treatment for oesophagitis

Clinical Question

What is the most effective treatment for reflux oesophagitis?

Bottom Line

Proton pump inhibitor (PPI) therapy is the most effective treatment for short-term (8wks) management of gastro- oesophageal reflux disease (GORD) - NNT= 1 to 2 (for PPI vs placebo). PPI better than H2 receptor antagonist (H2RA) but both superior to placebo. There is a paucity of evidence on prokinectic therapy but no evidence that it is superior to placebo.

Context

GORD is a common problem with an estimated prevalence of 20% in adults. PPIs and H2RAs relieve symptoms by reducing acid secretion in the stomach.

Caveat

In equivalent dosage different PPI preparations do not show statistically significant differences in their healing effects. Although there was an apparently higher disease persistence rate at the end of the treatment with double dose PPI compared to standard dose, this difference was not statistically significant.

Reference

Mostafizur Khan, Jose Santana, Clare Donnellan, Cathryn Preston, Paul Moayyedi. Medical treatments in the short term management of reflux oesophagitis. Cochrane Database of Systematic Reviews 2007, Issue 2. Art. No.: CD003244. DOI: 10.1002/14651858.CD003244.pub2. This review contains 134 trials with 35978 participants.

Cochrane Reviews 2007, Issue 1.

Date (Author) #19

May 2007 (Brian R McAvoy)

NNT = numbers needed to treat to benefit one person

NNH = numbers needed to harm to benefit one person

Both NNT and NNH are only reported if the studies or pooling of studies is statistically significant

Disclaimer : The P.E.A.R.L.S. are for educational use only and are not meant to guide clinical activity nor are they a clinical guideline.

Clinical Question	What is the most effective treatment for reflux oesophagitis?
Bottom Line	Proton pump inhibitor (PPI) therapy is the most effective treatment for short-term (8wks) management of gastro- oesophageal reflux disease (GORD) - NNT= 1 to 2 (for PPI vs placebo). PPI better than H2 receptor antagonist (H2RA) but both superior to placebo. There is a paucity of evidence on prokinectic therapy but no evidence that it is superior to placebo.
Context	GORD is a common problem with an estimated prevalence of 20% in adults. PPIs and H2RAs relieve symptoms by reducing acid secretion in the stomach.
Caveat	In equivalent dosage different PPI preparations do not show statistically significant differences in their healing effects. Although there was an apparently higher disease persistence rate at the end of the treatment with double dose PPI compared to standard dose, this difference was not statistically significant.
Reference	Mostafizur Khan, Jose Santana, Clare Donnellan, Cathryn Preston, Paul Moayyedi. Medical treatments in the short term management of reflux oesophagitis. Cochrane Database of Systematic Reviews 2007, Issue 2. Art. No.: CD003244. DOI: 10.1002/14651858.CD003244.pub2. This review contains 134 trials with 35978 participants. Cochrane Reviews 2007, Issue 1.
Date (Author) #19	May 2007 (Brian R McAvoy)