The Center for Modeling Optimal Outcomes® LLC, a New Jersey based think tank, has developed a new modeling technique for homeostasis that it believes shows a possible cause for autism.

The model appears to show that Autism Spectrum Disorders are triggered by disruptions in the homeostatic relationship of several variables:

“The Center’s Life Sciences group was able to formulate a scientifically verifiable model for the highly probable causal path of autism. Through the application of their model, it became apparent that autism is an outcome of several variables that, when the homeostatic relationship of each one is disrupted, a “perfect storm” scenario results in autism. The application of the model identified several of the variables that account for why boys have a 4 to 1 ratio of instances over girls as well as why not every boy is affected.

While the scientific community will have to validate The Center’s findings, the model for assessing homeostatic relationships indicates the “trigger” behind autism is an imbalance between a pair of amino acid neurotransmitters; glutamate and glycine.

According to The Center’s founder, William McFaul, a retired business person and not a member of the scientific community, “Because of its universal applicability, our Life Sciences group has already used the model as a tool to identify highly probable causal paths for several illnesses and disease entities. Autism was one of most difficult illnesses The Center had attempted to analyze. If it hadn’t been for so many parents insisting that vaccines were responsible for the condition, we might never have found the fact that the stabilizer in MMR and a few other vaccines is hydrolyzed gelatin; a substance that is approximately 21% glycine. It appears that, based on readily verifiable science, the use of that form of glycine triggers an imbalance between the amino acid neurotransmitters responsible for the absorption rate of certain classes of cells throughout the body. It is that wide-spread disruption that apparently results in the systemic problems that encompass the mind and the body characterized in today’s ‘classic’ autism.” He also added, “The use of our model indicates each of the disorders within Autism Spectrum Disorder (ASD) is attributable to different disruptions in homeostasis. We look forward to sharing our findings relative to each disorder with the scientific community.”

Of course the implications of the model are profound. Vaccine researchers and pharmaceutical companies will bristle at the mere suggestion that core vaccine ingredients like MSG and glycine are dangerous. Government regulators at the FDA, CDC and NIH will realize that they have failed adaquately protect the public so will likely try to remain in denial about this. Time will tell if the model can survive scientific scrutinty and produce useful results for researchers. If it persists it may well revolutionize medicine and nutrition.

You can see the entire press release here

Article Date: 19 Nov 2009 – 3:00 PST

During its research into the application of neuroscience in business, a New Jersey based think tank, The Center for Modeling Optimal Outcomes®, LLC (The Center) made an inadvertent and amazing discovery.

The Center examined the neuroscientific dynamics of logic and emotion in decision making while researching neuroscience in business. They found unique corollary relationships between various brain chemicals (neurohormones, neurotransmitters, etc.). This apparent pattern led to a new path of research for the team outside of business. By looking at extensive scientific literature they discovered a cascade of hormones that emanate from the brain (hypothalamus). This same pattern of correlations was again apparent throughout the cascade. The group added a research biologist and started to test the pattern on genes (proteins). It remained consistent. The Center then called upon advisors from chemistry and physics to see if the pattern would apply in physical sciences.

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J’adore les couleurs de l’automne!

Glycine wisteria floribunda macrobotrys dixit japonaise, novembre 2009

Ses feuilles prennent une douce couleur mordorée avant de former un tapis compact au sol qu’il faudra bien ramasser avant l’hiver. Les couleurs sont splendides! Et devinez quoi? Les cosmos sont toujours en fleurs…si si c’est incroyable…

Cosmos, novembre 2009

Le ciel est bien gris et il pleut vraiment beaucoup cet automne, alors heureusement que la couleur est présente sur le balcon !

Building block of life found on comet
By Steve Gorman

Composite Image of Comet Wild 2 by Stardust's Camera

The amino acid glycine, a fundamental building block of proteins, has been found in a comet for the first time, bolstering the theory that raw ingredients of life arrived on Earth from outer space, scientists said on Monday.

Microscopic traces of glycine were discovered in a sample of particles retrieved from the tail of comet Wild 2 by the NASA spacecraft Stardust deep in the solar system some 242 million miles (390 million km) from Earth, in January 2004.
Read the rest of this Reuters story

no, non sono impazzito. quando sono andato a scrivere sul search engine più braniac del web la parola glycine (n.d.r in realtà con un errore di battitura… glycrine) mi ha domandato “did you mean: glycerine?”. no caro bigG, voglio proprio glycine. una canzone dei bush non può vincere contro un amminoacido! anche google boicotta la scienza?

ma forse vi state domandando perchè cercavo glycine? beh, eccovi accontentati. la notizia è di quelle da far zompettare sulla sedia (n.d.r ok, magari non a tutti fa lo stesso effetto) e bisogna saltare indietro a qualche anno fa, nel 2004, quando la sonda stardust fece il famoso flyby con la cometa wild2. le notizie arrivarono quasi sovrapposte una all’altra, ma il sospetto che da quella polvere raccolta dalla sonda potesse venire qualche indicazione sull’origine della vita sulla terra era più che un’idea remota.

oggi sul sito del jpl è apparsa una notiziola: “first discovery of life bulding block in a comet”. il riferimento è proprio alla cometa wild2, e il “bulding block è proprio la glycine, un amminoacido utillizzato dagli organismi viventi per creare (as usual) delle proteine. il gioco è proprio questo: se venisse dimostrato che davvero la vita proviene dallo spazio, avremmo risolto una delle questioni più annose sulla nascita della vita sulla terra. non avremmo più bisogno di parlare di brodo primordiale (n.d.r che mi ricorda tanto i piatti coi passatelli che mangio in inverno), ma sposteremmo il nostro campo di osservazione verso lo spazio.

This article will demonstrate to you why Glutathione is so important to your health and well-being.

Glutathione (pronounced ‘gloota-thigh-own’) is the body’s essential health ABC’s – Antioxidant, Blood Booster and Cell Detoxifer.

It is a tripeptide composed of glutamic, cysteine and glycine. Glutathione is found in all cells in the body, including the bile, the epithelial lining fluid of the lungs, and – at much smaller concentrations – in the blood.

Glutathione is the smallest intracellular non-protein thiol (molecule containing an S_H or sulfhydryl group) molecule in the cells. This characteristic emphasizes its potent antioxidant action and supports a multifaceted thiol exchange system, which regulates cell activity.

This small protein, produced naturally in the body, maintains these three crucial protective functions.

In fact, your life depends on glutathione. Without it, your cells would disintegrate from unrestrained oxidation, your body would have little resistance to metabolic acids, and your liver would shrivel up from the eventual accumulation of acidic toxins.

Glutathione is not yet a household word. Even some medical and holistic doctors who have heard the term may still have only a vague idea of what it is. However, everyone will soon be talking about this critical non-nutritive substance.

There was a time when only scientists had heard of cholesterol and vitamins, but today, everyone knows about them. Now the magnificence of glutathione is becoming known.

In the last five years, over 25,000 medical articles about this substance have been published, and the scientific understanding of glutathione is gradually becoming common knowledge.

Each and every cell in the body is responsible for its own supply of glutathione and must have the necessary raw materials in order to produce it. Glutathione is always in great demand and is rapidly consumed when we experience any sort of emotional or physical stress, fatigue and even moderate exercise.

Some well-known causes of glutathione depletion are as follows:

1) Acidic lifestyle and diet 2) Air and Water pollution 3) Prescription and recreational drugs 4) Ultraviolet and Radiation from cells phones, computers, electrical cars, power lines, hair dryers, etc. 5) Emotional and physical stress 6) Injury, trauma or burns 7) Heavy metals 8) Cigarette smoke 9) Household chemicals 10) Acetaminophen poisoning 11) Exhaust from motor vehicles 12) Septic shock

All of these above factors lead to a build up of acidic toxins that cause the loss of glutathione as a non-nutritive buffer leading to cellular aging, disease and finally death.

Why is Glutathione Essential to Health?

Glutathione’s three major roles in the body are summarized by the letters A-B-C. – Anti-oxidant – Blood Booster – Cell Detoxifier

These are the three critical processes driven by glutathione. The Master Antioxidant Over the past thirty years, researchers have explored the role of antioxidants in good health as well as the treatment and prevention of diseases involving oxidation or fermentation by metabolic acids.

 Well known and widely used antioxidants such as vitamin A, vitamin E and selenium neutralize acid. They occur naturally in nature, but not in the body. They must be introduced as part of a balanced diet. Given the critical role of antioxidants in good health, it is not surprising that the body itself manufactures its own natural antioxidants. The most important of these is glutathione. Because all other antioxidants depend upon the presence of glutathione to function properly, scientists call it ‘the master antioxidant.’

Glutathione binds to toxins, forming a water-soluble complex – which is ultimately excreted in the urine or bile as waste.

Food for the Blood

Elevated glutathione levels enable the body to produce more white blood cells. White blood cells are the body’s garbage collectors and are the most important cells for maintaining sterility of the body fluids.

Glutathione plays a central role in the proper function of the white blood cells. Dr. Bustavo Bounous, a leading glutathione expert, says, ‘The limiting factor in the proper activity of our lymphocytes (the white blood cells) is the availability of glutathione.’ In other words, healthy growth and activity of the white blood cells depends upon glutathione’s availability. Put simply, glutathione is ‘food’ for the white blood cells.

Cellular Detoxifier

Whether we know it or not, we are continually inhaling and ingesting natural and synthetic acidic toxins. They are unavoidable in these modern times both in our polluted cities and our poorly engineered food supplies. When the body has the health and the nourishment it needs, it works tirelessly to eliminate acidic toxins and to protect itself. But, increasing levels of environmental pollution are depleting the body’s store of glutathione more and more rapidly. Our main organ of detoxification of acidic waste products is the lymphatic system and the liver. This is the body’s most concentrated source of glutathione.

Studies show that low glutathione levels lead to poor lymphatic and liver function, causing more and more acidic toxins to circulate through the body and resulting in damage to individual cells and organs.

Medical doctors today routinely use glutathione- promoting drugs to detoxify victims of certain types of drug overdose.

Glutathione in Natural Medicine

Practitioners of complementary and alternative medicine (CAM) have long advocated the use of milk thistle for liver problems. It turns out that this herb works by modestly elevating glutathione levels. The mineral selenium also produces subtle elevations in glutathione by becoming integrated into the glutathione peroxidase. Glutathione in Traditional Medicine

Emergency medical doctors, toxicologists and lung and liver specialists are well acquainted with glutathione’s therapeutic uses. American physicians seeking ways to raise a patient’s glutathione levels can open the standard Physician’s Desk Reference (PDR) and find two options – the pharmaceutical drugs sold under the names Parlodex and Mucomyst, and the natural dietary supplement found in natural foods stores derived from whey protein isolate.

Drugs That Raise Glutathione Levels Pharmaceutical drugs like Procysteine, OTC, OTX, Glutathione monoesters and Glutathione diesters have been used to raise glutathione levels. However, they all produce side effects and are unsuitable for long term use. This pharmaceutical non-nutritive chemical is used to break up mucus in lung diseases such as cystic fibrosis, chronic bronchitis and asthma. It remains the standard treatment for acetaminophen overdose.

Glutathione in Health and Disease

It is believed that glutathione has an important role to play in the prevention and treatment of disease. It may in the future be considered as important to health as an alkaline diet, exercise and alkaline lifestyle. Clinical tests show that raised glutathione levels may address some of the eight major health issues of our time:

1) Cardiovascular- Prevents heart disease – Shimizu H, Kiyohara Y, Kitazono T, Kubo M, Ibayashi S, Fufishima M, Lida M. Relationship Between Plasma Glutathione Levels and Cardiovascular Disease in a Defined Population: The Hisyama Study. Stroke. 2004 Sep; 35(9):2072-7. – Prevents stroke – Paterson PG, Juurlink BH. Nutritional Regulation of Glutathione in Stroke. Neurtox Res. 1999 Dec; 1(2): 99-112. – Prevents atherosclerosis – Coppola L, Grassia A, Giunta R. Glutathione Improves Hemostatic and Hemorrheological Parameters in Atherosclerotic Subject. Drugs Exp. Clin Res 1992 18:493-98 – Reverses artherosclerosis – Prevents reperfusion injury

2) Cancer 

Cancer causing polychlorinated biphenyls (PCBs) have been found to alter levels of glutathione compounds in experiments, which may alter the body’s resistance to certain types of cancer. Glutathione deficiencies have been linked to many forms of cancer. – Prevents cancerous tissue – Suppresses tumor growth – Eliminates carcinogen – acids – Retards oxidative stress – Prevents wasting disease – Eases side effects of chemotherapy and radiotherapy

3) Pulmonary 

Glutathione is the most efficient free radical (acid) scavenger in the airways, and dozens of studies have confirmed that free radical (acid) damage is a primary player in Chronic Obstructive Pulmonary Disease. Rahman I, MacNee W. Oxidative Stress and Regulation of Glutathione in Lung Inflammation. Eur Respir J. 2000 Sep; 16(3):534-54.

 - Breaks up mucus – Rahman I, MacNee W. Oxidative Stress and Regulation of Glutathione in Lung Inflammation. Eur Respir J. 2000 Sep; 16(3):534-54

 - Cystic fibrosis – Glutathione neutralized harmful oxidants introduced into the lungs or those released by cells. Exotoxins from bacteria can overload the endobronchial terrain and feed the fires of acidic inflammation. This staggering burden increases the oxidative sensitivity of the CF lung, resulting in further injury of lung parenchyma. Data supports evidence of a decrease in the antioxidant tri-peptide glutathione (Roum JH, Buhl R, McElvaney NG, et al. Systemic Deficiency of Glutathione in Systic Fibrosis. J Appl Physiol 1993; 75:19-24).

- Asthma

- Chronic bronchitis

- Emphysema – Lamson, David, MD, Grignall, Matthew, ND. The use of Nebulized Glutathione in the Treatment of Emphysema: A Case Report. Altern Med Review. 5(5);429-431, 2000 Oct.

- Pulmonary fibrosis – Ishii T, Fujishiro M, Nakajima J, Teramoto S, Ouchi Y, Matsuse T. Depletion of Glutathion S-Transferase P1 Induces Apoptosis in Huamn Lung Fibroblasts. Exp Lung Res. 29(7);523-36, 2003 Oct-Nov.

4) Aging

Glutathione is critically important to our brain as it is one of the most important brain antioxidants. Glutathione helps preserve brain tissue by preventing damage from free radicals (acids).

In addition to quenching dangerous acids, glutathione also acts to recycle vitamin E which also has the ability to reduce acidity in the brain. (Perlmutter D., BrainRecovery.com July 2004, 5th ed:13)

- Autism – Medical literature documents that an out-fection can lead to a lowering of glutathione which participates in detoxification, interacts with metallothioneins, and supports many crucial aspects of immunity. A link between glutathione and autism regression may derive from the fact that transient or chronic intestinal problems can impair an infant’s or toddler’s nutritional status, thereby minimizing the levels of amino-acids required for the production of glutathione (McCandless, J. Children With Starving Brains. 2003, 2nd ed; 252)

- Parkinson’s Disease – Glutathione helps to preserve brain tissue by preventing damage from free radicals (acids) and destructive chemicals formed by the normal processes of metabolism, toxic elements in the environment, and as a normal response of the body to challenges by acidic agents or other stresses. With the understanding that glutathione is important for brain protection and that this protection many be lacking in the brains of Parkinson’s clients due to glutathione deficiency, it can be seen as very beneficial. (Di Monte DA, Cahn P, Sandy MS. Glutathione in Parkinson’s Disease: A Link Between Oxidative Stress and Mitochondrial Damage? An Neurol. 32 Suppl; S111-115, 1992.)

- Alzheimer’s Disease – Woltjer, R.L., Hgheim W., Maezawa I., Vaisar T, Montine K.S., Montine T.J., Role of Glutathione in Intracellular Amyloid-Alpha Recursor Protein/Carboxy- Terminal Fragment Aggregation and Associated Cytotoxicity. J Neurochem. 2005 May; 93 (4): 1047-56. –

Huntington’s Disease – Choo Y.S., Mao Z, Johnson GV, Lesort M. Increased Glutathione Levels In Cortical Striatal Mitochondria of the R6/2 Huntington’s Disease Mouse Model. Neuroscience Letter. 2005 Sep 23; 386(1): 63-8.

- Multiple Sclerosis – Calabrese V, Scapaginini G, Ravagna A, Bella R, Butterfield DA, Calvani M, Pennisi G, Giuffrida Stella AM. Disruption of Thiol Homeostasis and Nitrostative Stress in the Cerebrospinal Fluid of Patients with Active Multiple Sclerosis: Evidence for a Protective Role of Acetylcarnitine. 2003 Sep; 28(9): 1321-8. Mann CL, Davies MB, Aldersea J, Fryer AA, Jones PK, Ko Ko C, Young C, Strange RC, Hawkins CP. Glutathione S-Transferase Polymorphisms in MS: Their Relationship to Disability. Neurology. 2000 Feb 8;54(3):542-7.

- ALS – Tohgi H, Abe T, Yamazaki K, Murata T, Ishizake E, Isobe C. Increase in Oxidized Products and Reduction in Oxidized Glutathione in Cerborospinal Fluid From Patients with Sporadic Form of Amyotrophic Lateral Sclerosis. Neurosci Lett. 1999 Feb 5; 260(3):204-6.

- Cataract formation

- Macular degeneration – Cancers of aging

- Prostate problems

- Osteoarthritis

 - Hammarqvist F, Luo JL, Cotgreave IA, Andersson K, Wernerman J. Skeletal Muscle Glutathione is Depleted In Critically Ill Patients. Crit Care Med. 25(1):78-84 1997 Jan.

5) Digestive

 - Inflammatory bowel disease

- Hepatitis

- Malnutrition

- Pancratititis

- Peptic ulcer

6) Toxicology

- Detoxifies certain drug overdoses - Acetaminophen has been shown to reduce glutathione production, thus paving the way for enhanced brain destruction by metabolic acids. (Perlmutter D. July 2004, 5th ed:108)

- Detoxifies substances in cigarette smoke and auto exhaust – Rahman I, MacNee W. Lung Glutathione and Oxidative Stress: Implications In Cigarette Smoke-Induced Airway Disease. Am J Physiol. 277(6 Pt 1);1067-88, 1999 Dec.

- Detoxifies pollutants including heavy metals and pesticides – Elevated glutathione levels have been shown to protect tissue form lipid peroxidation created by exposure to certain metals. Consider infusions of glutathione to relieve the body burden of both neurotoxins and metal toxicity, including mercury. (Foster, JS. Kane PC, Speight N. The Detox Book. 2002;90)

- Prevents hearing loss from noise pollution

- Detoxifies many well-known carcinogens

7) Immunology

- Anti-viral for AIDS, hepatitis, herpes, etc. – Low glutathione levels in HIV clients may contribute to their immune deficiency since glutathione plays an important role in the function of lymphocytes. Some lymphocytes require adequate levels of glutathione in order to function normally, and HIV induces oxidative stress that depletes the cells of glutathione. Townsend DM, Tew KD, Tapero H. The Importance of Glutathione in Human Disease. Biomed Pharmacother. 2003 May-June;57(3-4):145-55. Droge W, Holm E. Role of Cysteine and Glutathione in HIV Infection and other Diseases Associated with Muscle Wasting and Immunological Dysfunction. FASEB J, 11(13):1077-89 1997 Nov.

 - Lyme Disease – Lyme disease is a seriously complex multi-system acidic inflammatory condition that is triggered by bacterial exotoxins. Glutathione helps to remove exotoxic and/or mycotoxic acids by forming a soluble compound with them, which can then be excreted through the urine or gut. (Can Glutathione Help Lyme Disease Suffers? Excerpt from: The Glutathione Report: Opitmal Health with the Master Antioxidant, Issue 4, Volume 1, May 2004).

- Natural antibiotic

- Chronic fatigue syndrome – An article in the journal of Medical Hypothesis proposed that glutathione, an anitoxidant essential for lymphocyte function, may be depleted in Chronic Fatigue Syndrome patients. Glutathione is needed for both the immune system and for aerobic muscular contraction. The authors proposed that glutathione depletion by an activated immune system also causes the muscular fatigue and myalgia associated with Chronic Fatigue Syndrome (Bounous et al. 1999).

8) Metabolic

- Athletic enhancement

- Decreases recovery time from physical stress

- Supports hemoglobin in kidney failure

- Diabetes – The blood and tissues of diabetics are marked by critically low glutathione levels. Glutathione depletion may have adverse consequences in diabetic clients independent of glycemic control, and it may weaken the defense against oxidative stress. De Mattia G, Bravi MC, Laurenti O, Cassone-Faldetta M, Armiento A, Ferri C, Falsano F. Influence of Reduced Glutathione Infusion on Glucose Metabolism in Patients with Non-insulin Dependent Diabetes Mellitus. Metabolism. 1998 Aug;47(8):433-8.

 Glutathione provides the body with tools to fight off these threats naturally. Healthy people also benefit from elevated glutathione levels through an enhanced ability to fight off acidic toxins, disease, pre-cancerous cells and the aging process itself. Diminished glutathione levels are a symptom of aging and are particularly evident in such aliments as Parkinson’s disease and Alzheimer’s disease. Glutathione is also important to physically active people. Many world-class athletes are discovering that well-maintained glutathione levels gives them the edge over their competitors, bringing greater strength and endurance ,decreased recovery time from injury, less muscle pain and fatigue, and muscle-promoting activity.

 Putting It All Together

1) Medical science is still ascertaining all the critical roles played by glutathione in disease resistance and general good health. Clinical evidence links low glutathione levels to the most common illnesses of our time as well as newly emerging diseases.

2) As an essential aid to health, glutathione works as the master antioxidant in our body, optimizes the white blood cells and detoxifies a long list of pollutants and carcinogens or acids. The best way to raise glutathione levels is by eating foods that are high in glutathione such as avocados.

3) Pharmaceutical medicine has created drugs that do this very effectively. They have their uses in critical situations. But they also have side effects and repeated use is clearly inadvisable. _________________________________________________________

 References: Aging It is well known that aging is accompanied by a precipitous fall in glutathione levels. Lower glutathione levels are implicated in many diseases associated with aging including cataracts, Alzheimer’s, Parkinson’s atherosclerosis and others.

Journal of Clinical Epidemiology 47:1021-26, 1994.

Antioxidant Functions

Antioxidants are well documented and known to play vital roles in health maintenance and disease prevention. Glutathione is your cell’s own major antioxidant. Maintaining elevated glutathione levels aids the body’s natural antioxidant function.

Biochemical Pharmacology 47: 2114-2123, 1994.

Neurological Disease

Low glutathione levels have been associated with neuro-degenerative diseases such as MS (Multiple Sclerosis), ALS (Lou Gehrig’s Disease), Alzheimer’s and Parkinson’s. The Lancet 344: 796-798, 1994.

Cancer

Glutathione plays a role in eliminating many carcinogens/acids and also maintains and optimizes white blood cell function while providing stronger anti-acidic/anti-tumor defenses.

Cancer Letters 57: 91-94, 1991.

Athletic Performance

Raised glutathione levels help increase strength and endurance. Those interested in physical fitness can benefit from a definite athletic edge. Journal of Applied Physiology 87: 1381-1385, 1999.

Toxins, Pollution and Radiation

Glutathione detoxifies a variety of pollutants, carcinogens and poisons including many found in fuel exhaust and cigarette smoke. It also retards damage from radiation exposure due to the eroding ozone layer. Annual Reviews of Biochemistry 52: 711-760, 1983 AIDS

Glutathione levels correspond to poor survival of AIDS patients. Much documentation demonstrates the role of enhanced glutathione levels in AIDS.

Proceedings of the National Academy of Science, USA 94: 1967-72, 1997.

Heart Disease, Stroke and Cholesterol Raised glutathione levels fight the oxidation of fats circulating in the bloodstream including cholesterol, retarding the process of plaque formation in the arteries leading to most heart attacks and strokes.

Nutrition Reviews 54: 1-30, 1996.

Diabetes

Diabetics are more prone to ‘out-fections’ and circulatory problems leading to heart disease, kidney failure and blindness. Glutathione protects against the complications of diabetes.

Clinical Science 91:575-582, 1996

Lung Disease

Doctors have used glutathione-promoting drugs to treat many lung diseases including asthma, chronic bronchitis and emphysema. New and potentially therapeutic roles can be found for cigarette smoke damage, pulmonary fibrosis and other illnesses.

American Journal of Medical Science 307:119-127, 1994

Digestive Disorders

Glutathione protects the body from inflammation of gastritis, stomach ulcers, pancreatitis and inflammatory bowel disease including ulcerative colitis and Crohn’s disease.

Gut 42: 485-492, 1998

Hepatitis

The liver is a major storehouse for glutathione. Glutathione is impaired in alcohol hepatitis as well as in viral (acidic) hepatitis including hepatitis A, B, and C. Raised glutathione levels help restore liver function.

American Journal of Gastroenterology 91: 2569-2573, 1996

 Kidney Disease

Those with kidney failure or on dialysis suffer from high levels of oxidative (acidic) stress and decreased glutathione levels. Raised glutathione levels help prevent anemia. Nephron 61: 404-408, 1992

Pregnancy, Lactation and Childbirth

Glutathione’s role in fetal and placental development is critical. It also acts in the placenta to detoxify pollutants before they can reach the developing child. Many complications of pregnancy have been linked with poor glutathione levels.

Early Human Development 37: 167-174, 1994

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Le chant des cigales, une douce lumière filtrée par la glycine et la fraicheur d’une ancienne ferme…

… Souvenir d’un week end dans les Cévennes…

Today I thought I’d make a short list of the amino acids that had very low levels in the test so I can focus on these one at a time:

1-Threonine
2-Aspartic acid (Aspartate)
3-Methionine
4-Glycine
5-Asparagine (Made from 2-Aspartic acid)
6-Isoleucine

Below is a quick overview of each amino acid and the best source of food to eat.

Asparagine: Asparagine is needed to maintain a balance, preventing over nervousness. Aspartic Acid and Asparagine have high concentrations in the hippocampus and the hypothalamus. The hippocampus is a part of the brain that plays the main role in short-term memory, while the hypothalamus is involved in the biology of emotion, and serves as a neurological gate between the brain and the rest of the nervous system. Asparagine deficiency could be a contributing cause of fatigue and immune system stress including autoimmune disorders, infections and severe allergies. Asparagine is most commonly found in poultry, dairy, eggs, fish, lactalbumin, legumes, meat, nuts, seafood, seeds, soy, whey, whole grains, and beef.

Aspartic Acid: Aspartic Acid is a non-essential amino acid, existing mainly in the form of its amide, asparagine. It also performs an important role in the urea cycle and helping to transport minerals. Aspartic acid is a nonessential amino acid which is made from glutamic acid by enzymes using vitamin B6. The amino acid has important roles in the urea cycle and DNA metabolism.

Aspartic acid may also be a significant immunostimulant of the thymus and can protect against some of the damaging effects of radiation. Involved in immune system function by enhancing immunoglobulin production and anti- body formation. Calcium and magnesium deficiencies. Because of this association, low aspartic acid levels should lead the clinician to test for calcium and/or magnesium deficiencies. Aspartic Acid can be easily converted to glucose when demand for glucose exceeds supply. Aspartic acid plays an important role in the citric acid cycle, or Krebs cycle, during which other amino acids and biochemicals, such as asparagine, arginine, lysine, methionine, threonine, and isoleucine, are synthesized. Aspartic acid is found in high levels throughout the human body, especially in the brain, sprouting seeds, oat flakes, luncheon meats, sausage meat, wild game, avocado, asparagus.

Glycine: Glycine is an inhibitory neurotransmitter in the central nervous system, especially in the spinal cord. High concentrations of glycine are found not only in the muscles, but in the skin and other connective tissues as well. Almost 1/3 of collagen, which keeps the skin and connective tissue firm and flexible, is composed of glycine. (High amounts of Glycine are also found in gelatin, which is a form of denatured collagen). Without glycine the body would not be able to repair damaged tissues; the skin would become slack as it succumbed to UV rays, oxidation, and free radical damage, and wounds would never heal. Sources of glycine: High protein food contains good amounts of glycine and is present in fish, meat, beans, and dairy products.

Isoleucine: Nitrogen balance in adults. L-Isoleucine is a branched chain amino acid found in high concentrations in muscle tissues. Food sources include almonds, cashews, chicken, chickpeas, eggs, fish, lentils, liver, meat, rye, seeds, and soy protein.

Methionine: Methionine is a precursor for the other sulfur amino acids, cystine, taurine, and glutathione. Methionine plays a role in cysteine, carnitine and taurine synthesis by the transsulfuration pathway, lecithin production, the synthesis of phosphatidylcholine and other phospholipids. Methionine helps reduce histamine levels, which are amino acids that control dilation of blood vessels and influence brain function. Methionine is essential for the formation of healthy collagen used to form skin, nails, and connective tissue, and helps reduce the level of inflammatory histamines in the body. People with conditions linked to excessive histamine production, such as arthritis and chronic allergies, may benefit from methionine supplementation. Food sources include beans, eggs, fish, garlic, lentils, meat, onions, soybeans, seeds, yogurt.

Threonine: Required for formation of collagen. Needed by the gastrointestinal tract for normal functioning. Threonine is an important component in the formation of protein, collagen, elastin and tooth enamel. It is also important for production of neurotransmitters and health of the nervous system. Threonine is one of the immune-stimulating nutrients (cysteine, lysine, alanine, and aspartic acid are others), Threonine is found in most meats and fish, dairy foods, eggs, wheatgerm, bananas, carrots, nuts, beans and seeds. Rich sources of threonine include meats, dairy foods and eggs. Wheat germ, many nuts, beans, and seeds, and vegetables contains some small level of threonine.

Penemuan dari dua campuran yang kompleks mengisyaratkan keaneka-ragaman bahan kimia yang  bersembunyi di angkasa.

Suatu team riset internasional melakukan riset mendalam terhadap suatu awan yang berupa gas berada di pusat galaksi bima sakti dan mendeteksi adanya etil formate dan n-propyl sianida, dua di antara molekul organik paling kompleks yang pernah di amati di sistem luar matahari. Berdasarkan model komputer dan bukti spectroscopic bagaimana molekul dibentuk, ilmuwan percaya bahwa molekul dengan bahan kimia yang lebih kompleksitas lagi sedang menanti untuk ditemukan di angkasa.

Salah satu dari molekul itu adalah glycine, asam amino yang paling sederhana, yang terhindar dari pendeteksian sampai sekarang. Glycine adalah dua campuran yang memiliki ukuran dan  kompleksitas yang sama dan kehadiran nya akan membantu memperkuat  kecurigaan bahwa ilmu kimia prebiotik ada di sistem luar matahari kita.

Robin T.  Garrod salah seorang anggota riset adalah seorang ahli astrokimia di Cornell University, mengumumkan penemuan pada 21 April 2009 pada waktu European Week of Astronomy & Space Science di University of Hertfordshire, di Inggris. Penelitian ini  juga dilaporkan di jurnal Astronomi & Astrofisika (DOI: 10.1051/0004-6361/200811550).

Ulasan penemuan ahli Astrokimia Steven B.B. Charnley dari NASA’s Goddard Space Flight Center, di Greenbelt, Md., seperti yang dikatakan C&EN yang mendeteksi campuran ini membantu melepaskan cahaya baru dan bagaimana molekul yang kompleks dibentuk di angkasa dan ” dorongan untuk masa depan terhadap pencarian asam amino yang lebih tinggi, seperti halnya untuk nucleobases dan  tanda heterocyclic mereka .”

Peneliti menggunakan spektroskopi millimeter gelombang panjang untuk mempelajari suatu awan tebal dari gas dan partikel debu yang dingin  di daerah formasi bintang Sagittarius B2. Tempat  ini di alam semesta telah menjadi suatu harta terpendam yang banyak terdapat  molekul organic kecil yang berbeda jenis ( C&En, Juni 16, 2008, halaman 58). Meskipun demikian, mendeteksi etil formate dan n-propyl sianida sulit untuk ilmuwan sebab 36 garis spektrum mereka untuk dua campuran overlap dengan 3700 garis spektrum dari molekul banyak dideteksi orang.

Sumber: http://pubs.acs.org/cen/news/87/i17/8717notw3.html

… ce matin !  

Je serai un peu moins présente pendant quatre jours

pour cause petites vacances en Auvergne, entre copines

Un grand bras d’honneur, un majeur bien dressé à tous ces salauds qui font leur possible pour nous distraire avec leur fièvre porcine, qui essaient de répandre la terreur de la pandémie … pour quoi ? Comme d’habitude pour faire passer tranquille une pilule qu’on ne connaitra que dans quelques mois … une bonne vieille loi liberticide ? Un bon vieux décret mémoriel ? Une belle saloperie en tout cas, ça j’en suis bien sur, c’est pas la première fois, ce sera pas la dernière, parce que on a bien les gouvernants qu’on mérite, et leurs laquais aux ordres, journalistes plumitifs, porte-paroles et tutti quanti, pourriture et corruption …

alors grand bras d’honneur, doigt bien dressé !!! et pour aérer, pour passer de cette puanteur de merde à la belle et bonne odeur du printemps, ces photos prises hier dans le centre de Poitiers, puisque la Nature aura toujours le dernier mot…

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ça y’est c’est parti…Mes plantes sont en pleine effervescence…ça pousse!

La glycine en Avril 2009

C’est ma saison préférée, quand les feuilles emergent après la longue hibernation des plantes, elles ont une teinte vert clair…c’est plein de fraicheur et c’est tout particulièrement le cas de la glycine, qui plus tard prend un coloris plus foncé. J’attends impatiemment qu’elle court tout le long de la façade et je pense que d’ici 2 ans ce sera fait, vu la vitesse à laquelle elle pousse…en ce qui concerne les fleurs, ce n’est pas encore ça…on verra plus tard!

Pour le WE de Pâques, qui s’annonce frais mais ensoleillé…J’ai été piquer des mottes de primevères sauvages dans un jardin de ma maman en bourgogne. Rempottées, ces fleurs apportent une touche de gaieté à ce balcon printannier….bon certes c’est un peu léger…mais c’est toujours ça!

Primevères Sauvages, avril 2009

Au fait saviez-vous que primevère vient du latin “primo vere” qui veut dire “au début du printemps”? ah vous le saviez ? Bon il n’y a donc que moi qui aurait appris cela aujourd’hui!

Hello,

Ca fait quelques jours que je n’ai rien posté…je n’ai pas d’excuse à vous donner aujourd’hui! Mea Culpa! En fait, mon appareil photo est en réparation et … je peux toujours poster de vieilles photos…et bien c’est ce que je fais….donc pas d’excuses!

Aujourd’hui j’ai envie de vous parler de ma glycine.

C’était un rêve, un peu ma madeleine de proust…ha…une glycine. C’est pourquoi, quand j’ai eu ce balcon à aménager, je me suis dit que quoiqu’il arrivait, j’essayerais d’avoir une glycine : Qui ne tente rien n’a rien!

Glycine du Japon, plantée en 2007

Mon choix s’est donc porté vers une glycine du Japon, aussi appelée du doux nom imprononcable : “wisteria floribunda macrobotrys”.

C’est une grimpante caduc, à la croissance rapide, de la famille des légumineuse qui fleurie en mai sur des grappes de près d’1 mètre….La mienne est supposée être de couleur mauve. Je dis supposée car, jusqu’à aujourd’hui, elle ne fait que des feuilles, certes superbes mais bon…

La glycine du Japon macrobotrys existe en blanc et en mauve. Elle peut grimper jusqu’à 15m et nécessite une terre légère et fraiche mais beaucoup de soleil, ça tombe bien mon balcon est plein sud!

Donc je l’ai plantée en pot en 2007. J’ai donc pris un grand pot de 70cm de hauteur sur 40 cm de large (les racines ne s’étalent pas mais partent en profondeur). Au fond du pot, percé, j’ai installé un drainage de billes d’argiles sur 20cm. Ensuite, j’ai ajouté un feutre géotextile qui recouvre le tout et monte le long des parois pour accueillir la terre : un bon terreau avec environ 20% de tourbe, quelques billes d’argile et une dose d’engrais osmocotte à libération lente.

Je l’ai plantée avec une clematite Rosemoor, qui est splendide et se plait beaucoup à cet endroit. Il y a aussi, une lavande et un peu de thym serpolet. Je vous montrerais une photo dès que j’aurais récupéré mon appareil.

Les glycines sont rustiques mais n’apprecient ni trop d’humidité, ni le calcaire….vous avez compris, à Paris, vu l’eau calcaire que nous avons, c’est un problème…les feuilles ont tendance à jaunir ! Je met donc un peu de produit antichlorose au printemps et à l’automne (d’ailleurs, il ne faudrait pas oublier cette année),…ça ne fonctionne pas aussi bien que je le voudrais mais au moins elle continue à croître donc c’est mieux que rien.

Je me suis demandée si je ne rajouterais pas un jour, un peu de terre de bruyère pour acidifier le sol et compenser ainsi le  sol basique dû à mon arrosage en eau calcaire : je tenterais l’experience (en dernier recours) et vous raconterais.

wisteria floribunda macrobotrys, en 2007

En ce qui concerne la taille, c’est un peu rébarbatif mais nécessaire pour avoir des fleurs (chez moi ça ne marche pas encore)

En Juillet, il faut tailler toutes les longues tiges (dont vous n’avez pas besoin pour la structure de la plante) à 4 ou 5 yeux. Vous les taillerez à nouveau à 3 yeux en février. C’est tout! Attention, c’est une plante volubile qui est capable de tordre des grilles de fer, des toitures, gouttières…donc VIGILANCE!

Si vous ne voulez pas une glycine japonaise, il en existe des chinoises et même des américaines!

Au fait, un petit truc pour différencier la chinoise de la japonaise : les tiges de la japonaise s’enroulent dans le sens des aiguilles d”une montre ; la chinoise, c’est l’inverse. Si si c’est vrai!

When you imagine that earth is an oasis of life against the vast backdrop of lifeless universe, you may not be entirely wrong. But, space detectives think otherwise. They believe that universe might be teeming with raw materials of life and even rudimentary forms of life. One such life-giving molecules brewery has been detected on a far away galaxy.

Earth-based Arecibo Observatory radio telescope has homed in on molecules that build up amino acids, the basic building blocks for life as it unfolded on earth. The galaxy known as Arp 220 is 250 million light years away from earth. The molecules found are methanimine and hydrogen cyanide. Add water to these molecules, out comes glycine, the simplest amino acid that initiated the great journey of life on earth around 4 billion years ago.

‘As Dr. Pottenger was wont to say: “A big stock pot is the most important gift a bride could receive.”‘

Excerpts of this article were taken from Why Broth is Beautiful, By Kaayla T. Daniel, MS CCN.

I do recommend you read the entire article because there is so much to learn about this wonderful healing food; broth!

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“Fifty years ago Pottenger pointed out a reason that raw food diets can be so effective in reversing disease and contributing to rejuvenation. “Man’s food in the raw state consists largely of hydrophilic (water loving) colloids. (attracts digestive jiuces for rapid and effective digestions-according to SallyFallon) The heat of cooking on the other hand . . . precipitates the colloids of our diet. This change in colloidal state alters the hydration capacity of our foods so as to interfere with their ability to absorb digestive juices.” Happily for those who prefer their food cooked, Dr. Pottenger went on to explain that this digestive problem could be easily remedied by adding one-half ounce to one ounce of gelatin to a cooked meal of meat, potatoes, vegetables and fruits.”

Gelatin and the Liver

“Early research has also indicated that gelatin helps the liver. This is plausible in that the liver uses the amino acid glycine for detoxification, and its ability to detoxify is limited by the amount of glycine available. Back in 1935, Reuben Ottenberg, MD wrote in the Journal of the American Medical Association: “It has been suggested that the administration of extra amounts of proteins containing an abundance of glycine (such as gelatin) will help the work in the liver. This seems particularly plausible since the recent work of Quick, who has shown that the ability of the liver to perform this protective synthesis is limited by the amount of glycine available.”

Ottenberg concluded with the recommendation that patients with jaundice and other liver problems take 5 to l0 grams of gelatin per day either in the form of food or as a powdered medicinal supplement.

The big question is why so many early studies showing the healing power of gelatin have languished in obscurity. The easy explanation is that after the 1930s, pharmaceutical drugs were widely prescribed for ills that were once healed with gelatin.

Most commercial gelatins today are brewed exclusively from pigskins or cowhide and so include no cartilage or bones. Years ago, however, some commercial cartilages came from mystery blends of cartilage, bones, skin and other junked animal parts. All these combinations differed in terms of their physical and chemical characteristics and in their physiologic actions. Gotthoffer reported that even glue was sometimes sold as gelatin. Complicating matters further, some of the so-called “gelatin” studies were done with the isolated amino acid glycine.”

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“Remember also that the amino acids in gelatin, like all amino acids, can only be properly utilized when the diet contains sufficient fat-soluble activators–vitamins A and D–found exclusively in animal fats. So don’t hesitate to put cream in your broth-based soups and sauces, and include other sources of vitamins A and D in your diet, such as butter, egg yolks and cod liver oil.”

In your next bowl of broth or soup, whisk in a raw egg yolk for added nourishment. You won’t taste it at all. Of course make sure you know the source of your eggs, before eating them raw.

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According to Sally Fallon in Nourishing Traditions, there are many other important ingredients that go into broth . Cartilage is one that has recently been shown to be remarkable in treating cancer and bone disorders. Collagen has been used successfully in treating rheumatoid arthritis and it’s especially necessary for those of us with Lyme Disease. Spirochetes feed on collagen, so it’s important to nourish your body with broths and to use products with MSM added in like Dr Ron’s body care products.

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Cooking bone broth is very easy and effortless. When our steer is processed for the freezer, we make sure to ask for all the bones. You can take 2-3 good size bones and throw them in a stock pot of water. It’s recommended to add a dash of ACV (apple cider vinegar), due to it’s ability to draw out more minerals and calcium from the bones. I cook all my stocks, whether chicken or beef, all day (8-10 hrs). At night I put the pot in the extra frig and pull it out in the morning and cook it another 10 hrs. I’ve never had a pot not gel. Mine gel all the way through.

When I use one of our chickens for grilling, I collect all the backs and necks in a ziplock in the freezer. After I have a few then I can make a pot of chicken stock. It’s a bit tedious to pick out all the tiny little bones. But since they are cooked to the point of almost dissolving, it’s not a big deal to get one and chew it up….hey, more nourishment! And make sure when you get your fresh chickens you request the heads and feet too! They hold the secret to what is fondly referred to as Jewish Penicillin.

If I’m planning to make a pot of chicken soup or beef vegetable, I wait until the second day and after cooking another 4-5 hrs, I then add the veggies. If I want some plain stock then I’ll skim some off to freeze. It’s great having nourishing little stock cubes (freeze in ice cube trays), that can be thrown in whatever you’re cooking; sauces, rice dishes, veggies. I spend many a winter day, cooking pots of stock and freezing containers of chicken or beef soup. They make a great quick meal and are extremely healthy during the winter months, as well as all year.

]]> http://rebello.wordpress.com/2008/06/20/meteorite-holds-important-clues-to-the-origin-of-the-solar-system/ Fri, 20 Jun 2008 18:16:26 +0000 tommypaine http://rebello.wordpress.com/2008/06/20/meteorite-holds-important-clues-to-the-origin-of-the-solar-system/

London’s Natural History Museum has acquired the Ivuna Meteorite, which fell to earth in Tanzania in 1938, and has the same chemical makeup as the sun. This extremely rare space rock could lead scientists to a better understanding of how our solar system was formed nearly 4.5 billion years ago.

Article from BBC News.