Tags » Meta-analysis

Due dilligence in ALS research

Steve Perrin in a recent issue of NATURE (Vol 507, p.423) summarizes the struggle of the amyotrophic lateral sclerosis (ALS) field to explain the multiple failures of clinical trials testing compounds to improve the symptoms and survival of patients with this disease. 96 more words


Have the ARRIVE guidelines been implemented?

Research on animals generally lacks transparent reporting of study design and implementation, as well as results. As a consequene of poor reporting, we are facing problems in replicating published findings, publication of underpowered studies and excessive false positives or false negatives, publication bias, and as a result difficulties in translating promising preclinical results into effective therapies for human disease. 250 more words


Five studies claimed to demonstrate efficacy of psychotherapy for depression in cancer patients

At my primary blog site, PLOS Mind the Brain I am critically discussing an article for which this post provides some resources helpful for readers in forming their own opinions. 1,694 more words


Some exercise is better than none; more is better to reduce heart disease risk

Public release date: 1-Aug-2011

Even small amounts of physical activity will help reduce heart disease risk, and the benefit increases as the amount of activity increases, according to a quantitative review reported in Circulation, journal of the American Heart Association.

United States

Understanding out of Chaos

Many Causes, One Disease, Many Cures
Resolving Multiple Factors for Disease States

“Double, double toil and trouble
Fire burn, and cauldron bubble” Hamlet, Shakespeare

Okay, this post is not for the layman in trying to resolve issues of their personal health. 1,575 more words


Including trials reporting medians in meta-analysis

I’ve been thinking a lot about how best to include trials that report incomplete stats (or just not the stats you want) in a meta-analysis. This led me to a… 177 more words


Data detective work: work out the numerator or denominator given a percentage

Here’s some fun I had today. If you are looking at some published stats and they tell you a percentage but not the numerator & denominator, you can still work them out. 451 more words