Blogs about: Multikinase
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Researchers publish new GSK3 kinase inhibitors
Researchers from the Univ Athens, Station Biologique and Vanderbilt University have published a series of GSK-3 kinase inhibitors that can alter circadian rhythm… more →
Kinase News
Researchers publish new GSK3 kinase inhibitors
crimsoncanary wrote 1 year ago: Researchers from the Univ Athens, Station Biologique and Vanderbilt University have published a seri … more →
Bayer/Onyx initiate new Phase III trial for Nexavar in liver cancer
crimsoncanary wrote 1 year ago: Bayer and Onyx have announced the initiation of a Phase III study of Nexavar (sorafenib) as an adjuv … more →
Sunitinib and Sorafenib cause Erythrocytosis, Indicative of class effect?
crimsoncanary wrote 1 year ago: Researchers report that the development of reversible erythrocytosis is a common side effect followi … more →
Sorafenib in Neurofibromatosis/Neurofibromas
crimsoncanary wrote 1 year ago: The NCI are initiating a phase I trial of Sorafenib in Treating Young Patients With Neurofibromatosi … more →
NICE recommends against Avastin, Nexavar, Sutent and Torisel for Kidney Cancer
crimsoncanary wrote 1 year ago: The UK’s National Institute for Health and Clinical Excellence (NICE) has made a preliminary r … more →
Sorafenib and Bevacizumab combination therapy increases antitumor activity
crimsoncanary wrote 1 year ago: Combining Sorafenib and Bevacizumab has been shown to increase antitumur activity in patients with a … more →
Nexavar approved for hepatocellular carcinoma in China
crimsoncanary wrote 1 year ago: Bayer and Onyx have announced that Nexavar has been approved for the treatment of patients with unre … more →
Sorafenib shows efficacy in Phase III hepatocellular carcinoma trial
crimsoncanary wrote 1 year ago: Sorafenib has been shown to be effective in patients with advanced hepatocellular carcinoma. The med … more →
Genentech halt Avastin/Sutent trial following cases of microangiopathic hemolytic anemia (MAHA)
crimsoncanary wrote 1 year ago: Genentech have halted its trial of Avastin in combination with Sutent following reports of several c … more →
Sunitinib shows efficacy in the treatment of Advanced Neuroendocrine Tumors
crimsoncanary wrote 1 year ago: Sunitinib has shown efficacy in a phase II study of pancreatic neuroendocrine tumor patients. … more →
Exelixis begin Phase II trial of multikinase inhibitor XL184 in Glioblastoma Multiforme
crimsoncanary wrote 1 year ago: Exelixis are initiating a Phase II trial of XL184 for the treatment of Malignant Glioma … more →
Abbott publish series of multikinase inhibitors
crimsoncanary wrote 1 year ago: Abbott have published a series of 7-Aminopyrazolo[1,5-a]pyrimidine urea receptor tyrosine kinase inh … more →
Phase II data shows Sorafenib to demonstrate efficacy in advanced thyroid cancer
crimsoncanary wrote 1 year ago: Phase II data show sorafenib to demonstrate efficacy in patients with advanced thyroid carcinoma. Th … more →
Phase II data show GSK’s pazopanib to demonstrate efficacy in NSCLC and renal cancer
crimsoncanary wrote 1 year ago: Phase II data presented at ASCO show GSK’s multikinase inhibitor pazopanib to demonstrate effi … more →
Nexavar clinical data presented at ASCO
crimsoncanary wrote 1 year ago: Lung cancer – Phase II results show ‘encouraging’ results in heavily pre-treated p … more →
Ariads Multikinase inhibitor AP24534 enters Phase I
crimsoncanary wrote 1 year ago: ARIAD has initiated a phase I clinical trial of its Investigational Oral Multi-Targeted Kinase Inhib … more →
Nexavar improves survival in liver cancer by 47percent
crimsoncanary wrote 1 year ago: Nexavar (sorafenib) has been shown to significantly improve overall survival by 47.3% in a phase III … more →
Sorafenib shows broader anti AML cell activity than Imatinib or Sunitinib
crimsoncanary wrote 1 year ago: In vitro analysis of multikinas inhibitors imatinib, sorafenib, and sunitinib in human AML cell line … more →
Kirins kinase inhibitor Ki-11502 shows activity against PDGF
crimsoncanary wrote 1 year ago: In eosinophilic leukemia EOL-1 cells Ki11502 was found to decrease levels of p-PDGFR and its downstr … more →
