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First-in-class thyrotropin-releasing hormone (TRH)-based compound binds to a pharmacologically distinct TRH receptor subtype in human brain and is effective in neurodegenerative models

First-in-class thyrotropin-releasing hormone (TRH)-based compound binds to a pharmacologically distinct TRH receptor subtype in human brain and is effective in neurodegenerative models

Highlights

  • First-in-class TRH-based compound JAK4D detects new receptor subtype in human brain.
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Estrogen receptor expression may help explain why more males have autism.

The same sex hormone that helps protect females from stroke may also reduce their risk of autism, scientists say.  In the first look at a potential role of the female sex hormone in autism, researchers at the Georgia Regents University have found expression of estrogen receptor beta, which enables estrogen’s potent brain protection, is significantly decreased in autistic brains. 641 more words

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