Blogs about: Paxil
Sex, Psych Drugs and The MOTHERS Act - Young Couples Beware
Amy Philo wrote 1 month ago: Sex and Psych Drugs – Young Couples Beware by Evelyn Pringle June 2, 2009 Although the advers … more →
Conflicting evidence on Tamoxifen and anti-depressants
JBBC wrote 1 month ago: Women who take anti-depressants, while on tamoxifen, may or may not be at risk of recurrence. Accord … more →
half a year, in a relationship
kalengirl wrote 1 month ago: My boyfriend and I have been together for almost 6 month, but or first fight was a couple of weeks a … more →
Quitting Paxil # 6
kalengirl wrote 1 month ago: I’m taking at the moment 5 mg every day. Until now the only side effect I’m having is di … more →
Quitting Paxil #5
kalengirl wrote 1 month ago: Yesterday I started taking only 5mg each day. the first side effect I felt was a anxiety attack whil … more →
My First Fight in a Relationship
kalengirl wrote 2 months ago: my boyfriend and I had or first real fight last Sunday. let me tell you the story from the beginning … more →
Quitting Paxil #4
— 4 comments
kalengirl wrote 2 months ago: I’m still lowering the dose of Paxil, on the 23 I will go down to 5mg every day. It is not an … more →
Researchers evaluate SSRIs against older antidepressants, each other.
abrandemihl wrote 2 months ago: Medscape (5/14, Anderson) reported that, according to a meta-analysis published Apr. 15 in the Cochr … more →
Adrienne Einarson responds to Vogue's "Pregnant Pause"
Lauren wrote 2 months ago: On April 29, I posted a piece entitled Thoughts on exploring a “Pregnant Pause” Focused … more →
Invite...book reading!!!
bethann17 wrote 2 months ago: Come join me in a reading of my book! I am so excited to be sharing it with you all… Pampered … more →
My Baby's Smile. My Journey and Recovery Through Postpartum Depression.
bethann17 wrote 2 months ago: Book is also now listed on www.Ebay.com If ordered on Ebay it will be mailed out signed and with any … more →
Now a major new study suggests that both critics and proponents might be right about SSRIs: the drugs can work, but they appear to work best for only a subset of depressed patients — those with a limited range of psychological problems. People whose depression is compounded with, say, substance abuse or a personality disorder may not get much help from SSRIs — which is unfortunate for the 45% to 60% of patients in the U.S. who have been diagnosed with a common mental disorder like depression and also meet the criteria for at least one other disorder, like substance abuse. (Multiple diagnoses are known in medical parlance as comorbidities.) The new study, published online in April by the American Journal of Psychiatry, was conducted using data from a large, government-funded trial called Sequenced Treatment Alternatives to Relieve Depression, which usually goes by the moniker STAR*D. The STAR*D project, which collected data from 2001 to 2004 at 41 U.S. psychiatric facilities, was one of the most ambitious efforts ever to understand how best to treat people with major depression. STAR*D participants comprise a powerful research sample because they are highly representative of all depressed Americans. Very few depressed people were excluded from STAR*D; only women who were pregnant, those with seizure disorders and a few others with acute conditions were kept out. All other psychiatric and medical comorbidities were allowed. The authors of the new paper, a team of 11 researchers led by University of Pittsburgh professor of epidemiology Stephen Wisniewski, were curious how the STAR*D group would compare with a typical group of patients selected for a run-of-the-mill drug-company trial for a new antidepressant — the very trials on which the Food and Drug Administration bases its decisions regarding new drug approval. Drawing on their own experiences in helping to conduct such trials, which have far more stringent inclusion criteria than the STAR*D group, Wisniewski and his team divided the STAR*D patients into two groups — an "efficacy" sample of patients who would normally be included in a typical Phase III clinical trial for a new antidepressant and a "nonefficacy" sample of patients who would normally be rejected. Depressed STAR*D patients who were classified for inclusion had no more than one general medical condition (like, say, heart disease) and no more than one additional primary psychiatric disorder besides depression. All patients with multiple comorbidities — along with anyone whose depression had lasted more than two years — were excluded. Once the authors crunched all the numbers, they found that only 22% of STAR*D patients met entry criteria for a conventional antidepressant trial. All the STAR*D patients were taking citalopram, an SSRI marketed in North America as Celexa. Not surprisingly, those who met standard inclusion criteria for a clinical trial had significantly better outcomes on the drug. In the efficacy group, 52% responded to Celexa vs. 40% of the nonefficacy group. Patients in the latter group also took longer to respond and had to be readmitted to psychiatric settings more often. "Thus," the authors conclude, "current efficacy trials suggest a more optimistic outcome than is likely in practice, and the duration of adequate treatment suggested by data from efficacy trials may be too short." To bolster their findings, the authors cite a smaller 2002 study that arrived at similar results: in that paper, published in the American Journal of Psychiatry, Dr. Mark Zimmerman of Brown University and his colleagues found that of 315 patients with major depressive disorder who sought care, only 29, or 9.2%, met typical criteria for an efficacy trial. Similarly, psychologist Ronald Kessler of Harvard co-authored a 2003 paper in the Journal of the American Medical Association that concluded that most "real world" patients with major depression would be excluded from clinical trials because of comorbidities. Such findings help explain why antidepressants haven't quite lived up to their promise. But the University of Pittsburgh's Wisniewski, the lead author of the new study, cautions against interpreting the results as an indictment against greedy drug companies eager to exclude difficult patients in order to show better results. "If the population in a [clinical] trial were more representative, that would come at a cost," he says. Researchers expect a certain number of bad reactions during clinical trials; some of these reactions can cause serious medical problems. If patients enter a trial with multiple complications — if they are, say, not only depressed, but also cocaine-addicted, hypertensive and diabetic — you dramatically increase the chances of adverse side effects. "That's why trials to determine efficacy are done on a relatively homogeneous population," Wisniewski says. That's understandable, but the new study does shed light on the limitations of antidepressants. Conducting clinical trials with representative samples would undoubtedly be more complex — and expensive — since patients with multiple risk factors would have to be monitored more carefully. But for a future generation of antidepressants to be truly effective for most patients, more-inclusive trials may be the best answer.
akamine2525 wrote 2 months ago: From 2008:Popular antidepressants including Prozac and Paxil have little impact on most patients, ac … more →
My own autistic son...
richardaaron1919 wrote 2 months ago: A very big aspect of Gauntlet is that it was written based on my own autistic son. I wanted to write … more →
Keep Me Where The Light Is
— 1 comment
Brian wrote 2 months ago: It’s easy to get reflective and pensive on this anniversary of my birth, but I will try to ref … more →
Postpartum Depression-Help in South Florida
bethann17 wrote 2 months ago: http://www.postpartumsupport.com/director.htm I found this wonderful support center on www.postpartu … more →
Our bodies get bigger but our hearts get torn up.
— 1 comment
liquiterge wrote 2 months ago: Christ, is the Swine Flu really getting to be that bad? We wasted a total of an hour ON FRIDAY for a … more →
Quitting Paxil #3
kalengirl wrote 2 months ago: Yesterday I had to go to the doctor to get something for my diarrhea… After taking the medicin … more →
Another great article on SSRIs
bethann17 wrote 2 months ago: TREATMENTS FOR DEPRESSION Drugs known as antidepressants CLASS:- “SPECIFIC SEROTONIN RE-UPT … more →
Sunflower Seeds are Answer from Nature to Antidepressant Drugs
sakerfa wrote 2 months ago: Sunflowers are the earthly representation of the sun. They have such an affinity for the life giving … more →
Have your say. Start a blog.
See our free features →
An 
Opus
