Blogs about: Pdgf
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Millennium present data on kinase programs at EORTC-NCI-AACR meeting
Data presented at the EORTC NCI AACR meeting detail data and progress on Millennium kinase programs: MLN8237 – Aurora A – Phase II trials expected in late 2008/early 2009 TAK-285 – … more →
Kinase News
Stem Cells in Dentistry ?!?
robertgougaloff wrote 1 year ago: Absolutely !! Oral Surgery in general and bone grafting in particular are starting to make a transi … more →
Millennium present data on kinase programs at EORTC-NCI-AACR meeting
crimsoncanary wrote 1 year ago: Data presented at the EORTC NCI AACR meeting detail data and progress on Millennium kinase programs: … more →
Imatinib shows potential in pulmonary arterial hypertension (PAH)
crimsoncanary wrote 1 year ago: Phase II data presented at the European Respiratory Society show Imatinib to demonstrate efficacy in … more →
Gleevec receives priority review in US for GIST after surgery
crimsoncanary wrote 1 year ago: Gleevec (imatinib) has been granted priority review status by the US Food and Drug Administration (F … more →
Imatinib in connective tissue diseases
crimsoncanary wrote 1 year ago: Three papers in this months Arthritis and Rheumatism discuss Imatinib in connective tissue diseases: … more →
Retrospective study shows imatinib treatment induces hypogammaglobulinemia
crimsoncanary wrote 1 year ago: A retrospective study of 72 chronic myeloid leukemia and 15 gastrointestinal stromal tumor patients … more →
Kinase Domain Mutation detection indicates risk of disease progression
crimsoncanary wrote 1 year ago: Researchers from Imperial College London have published data showing that screening of patients for … more →
Amgens Motesanib demonstrates efficacy in Thyroid Cancer
crimsoncanary wrote 1 year ago: Phase II data published in the NEJM show Amgen’s Motesanib (AMG706) to induce partial response … more →
Resistance to imatinib (Gleevec) caused by LYN kinase
crimsoncanary wrote 1 year ago: Data published in this weeks Journal of the National Cancer Institute shows that activation of LYN k … more →
Imatinib increases thrombolytic therapeutic window in stroke
crimsoncanary wrote 1 year ago: Researchers from the University of Michigan and the Karolinska Institute have found that imatinib (G … more →
Rhabdomyolysis - possible adverse effect of Imatinib
crimsoncanary wrote 1 year ago: In a letter to the New England Journal of Medicine French doctors have reported a case of severerhab … more →
High initial dose of Gleevec results in better early responses in CML
crimsoncanary wrote 1 year ago: New phase III data shows that when Gleevec is administered at a high initial dose (800 mg/day) there … more →
Imatinib modulates synovial fibroblasts in arthritis model
crimsoncanary wrote 1 year ago: Data presented at EULAR shows that PDGFR kinase inhibitors can modulate synovial fibroblast activity … more →
Anti-fibrotic effect of Imatinib does not appear to affect vasculature
crimsoncanary wrote 1 year ago: Data presented at EULAR show Imatinib does not inhibit proliferation, migration or tube forming in e … more →
Imatinib in C-Kit or PDGFR-β expressing metastatic breast cancer
crimsoncanary wrote 1 year ago: Imatinib mesylate was tested in patients with metastatic breast cancer expressing PDGFR or c-kit. No … more →
Imatinib in long term treatment of Chronic Myeloid Leukemia
crimsoncanary wrote 1 year ago: Researchers from Imperial College London have published data on long term (5 yr) treatment of Chroni … more →
Imatinib enters Phase II trial for Nephrogenic Systemic Fibrosis
crimsoncanary wrote 1 year ago: Novartis have initiated a Phase 2 Pilot Study of Imatinib (Gleevec) for Nephrogenic Systemic Fibrosi … more →
Kirins kinase inhibitor Ki-11502 shows activity against PDGF
crimsoncanary wrote 1 year ago: In eosinophilic leukemia EOL-1 cells Ki11502 was found to decrease levels of p-PDGFR and its downstr … more →
