Stereoscopic model of PEDF

Link between obesity and diabetes discovered

Researchers at Monash University (led by Associate Professor Matthew Watt), have discovered that fat cells release a novel protein called PEDF (pigment epithelium-derived factor), which triggers a chain of events and interactions that lead to development of Type 2 diabetes.

According to Dr. Watt:

• When PEDF is released into the bloodstream, it causes the muscle and liver to become desensitized to insulin. The pancreas then produces more insulin to counteract these negative effects
• This insulin release causes the pancreas to become overworked, eventually slowing or stopping insulin release from the pancreas, leading to Type 2 diabetes.
• It appears that the more fat tissue a person has the less sensitive they become to insulin. Therefore a greater amount of insulin is required to maintain the body’s regulation of blood-glucose.

Our research was able to show that increasing PEDF not only causes Type 2 diabetes like complications but that blocking PEDF reverses these effects.

In fact, after blocking the secretion of PEDF in test subjects, the body was able to return to being insulin-sensitive and therefore did not need excess insulin to remain regulated.

This research may be a significant breakthrough in explaining the reasons why obesity triggers the onset of Type 2 Diabetes.

Until now scientists knew there was a very clear pattern and had strong suspicions that a link existed between the two conditions, but our understanding of the chain of events that are caused by the release of PEDF shows a causal link, Dr. Watt said.

Type 2 diabetes patients will benefit knowing the two conditions are linked.

We already know that weight-loss generally improves the management of blood glucose levels in diabetes patients.

Researchers can now move forward knowing this link exists and can begin to design new drugs to improve the treatment of Type 2 diabetes….

…or perhaps, instead of looking for a cure for this completely preventable lifestyle disease, we could throw some cash at health promotion and/or disease prevention.

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Reference

• Monash University Press Release
• Study Abstract
• Scientific info on PEDF

Na Univerzitě Karlově “funguje” systém Urudio. Má studentům a vyučujícím usnadnit život. Má, ale nedělá to. Možná to není přímo systémem ale adminem. Možná ani ne adminem, ale vedením.

Jeden, nejnovější, příklad za všechny.

Dnes, v 9:00, začíná zápis do předmětů, jak jinak než přes Erudio. Včera se na fakultních stránkách PedF objevila zpráva, že dnes od 9:00 začíná úprava systému Erudio a s největší pravděpodobností se systém stane nedostupným.

STALO SE!

Nevím kdo rozhodl o čase úpravách systému, ale normálně myslící člověk, a nemusí být ani systémový administrátor, naplánuje takové úpravy na čas kdy je systém nejméně zatížen a né když se stovky a tísíce lidí najednou přihlásí do systému a potřebují řešit nutné věci.

Pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in aged human choroid and eyes with age-related macular degeneration.

Down-regulation of PEDF mRNA

Eye and Retina – Structure

PlGF and CNV