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Tolerance Induction and Reversal of Diabetes in Mice Transplanted with Human Embryonic-Stem-Cell-Derived Pancreatic Endoderm

Bhaskar Chanda Stem Cell Szot et al. demonstrate that targeting T cell costimulatory pathways prevents rejection of xenogeneic human embryonic-stem-cell-derived pancreatic endoderm (hESC-PE) in mice and allogeneic hESC-PE in humanized mice. 33 more words


Perivascular Gli1 Progenitors Are Key Contributors to Injury-Induced Organ Fibrosis

Bhaskar Chanda Stem Cell The cellular origins of fibrosis in different tissues are unclear. Kramann et al. show that Gli1 marks a network of perivascular mesenchymal-stem-cell-like cells that generate myofibroblasts and play a central role in organ fibrosis after injury, and ablating these cells ameliorates fibrosis and rescues organ function. 13 more words


SCNT-Derived ESCs with Mismatched Mitochondria Trigger an Immune Response in Allogeneic Hosts

Bhaskar Chanda Stem Cell Deuse et al. report that SCNT-derived mouse ESCs trigger an immune rejection in spite of their matching with the entire nuclear genome of the recipient mouse strain. 26 more words


Plasticity and Dedifferentiation within the Pancreas: Development, Homeostasis, and Disease

Bhaskar Chanda Stem Cell Cellular identity is established by genetic, epigenetic, and environmental factors that regulate organogenesis and tissue homeostasis. Although some flexibility in fate potential is beneficial to overall organ health, dramatic changes in cellular identity can have disastrous consequences. 76 more words


TSU Tigers slow start, high expectations

Houston—Texas Southern University Men’s basketball had started the season a bit slow as they drop the first two games of the year.

The defending SWAC champions have had their work cut out for them early on as the loss margin is an average of 22.5 points per game (ppg). 251 more words