” showed that they posed a cardiovascular hazard, similar in magnitude to that resulting from being a smoker or a diabetic “
04 May 2012… 957 more words
The COX-2 enzyme, on the other hand, works to synthesize prostacyclin from essential fatty acids. Prostacyclin helps prevent platelets from clumping and promotes blood vessel dilation and inflammation and in high concentrations can drill holes through weak stomach linings. 30 more words
Within the last two weeks Federal health officials conceded that the same sort of dangers associated with Vioxx apply, too, to Celebrex. Three days after the Celebrex warning, a warning was issued concerning what was always considered a relatively benign, over the counter product, Alieve. 21 more words
One internal email dated as early as 1996 during development, reveals an awareness at Merck of the potential hazards. Over time evidence mounted and by 2004 the danger of heart attack and stroke became so obvious, especially for higher intake levels and long term use, the manufacturer decided to remove all Vioxx from its shelf.
Total sales for the two products in the United States alone for the year 2003, came to $4.5 billion. Since its approval date in 1999 nearly 91 million prescriptions have been written for Vioxx.