PAW #12 is about John Kennedy Toole, the ill-fated would-be novelist whose book A Confederacy of Dunces was repeatedly rejected by publishers throughout his life, which Toole prematurely ended when he gassed himself in his car in Mississippi, aged 31. 28 more words
This encapsulates what makes xkcd so great. The characters lampoon the procedures of daily life through technology and clever non sequitur. Easy to reference, this comic is hilarious and a great introduction to the website.