Tags » Allergy

Successful management of hereditary angioedema during pregnancy in a patient with heterozygous MTHFR mutation

Hereditary angioedema (HAE) caused by C1-esterase inhibitor (C1-INH) deficiency is a rare, autosomal dominant disorder. Type 1 HAE makes up 85% of cases and is caused by reduced circulating levels of C1-INH, whereas type 2 HAE is caused by dysfunctional circulating C1-INH despite normal levels.1 Symptoms of type 1 and 2 HAE may include abdominal symptoms and episodes of swelling of the face, genitalia, extremities, urinary tract, and upper airways. 18 more words

By Alexandros G. Sfakianakis

Optimal needle length for epinephrine prefilled syringe in children

Patients with a history of anaphylaxis have a strong indication for the use of epinephrine auto-injectors (EAIs).1 However, EAIs are available in only 59.1% of countries according to a recent report from the World Allergy Organization.2 Appropriate EAI needle length for delivering epinephrine into intramuscular tissues has been studied in adults3–5 and children.6–8 EAIs also require a pressure trigger for delivery of epinephrine, which compresses the subcutaneous tissues and thus shortens the skin-to-muscle depth (STMD).


By Alexandros G. Sfakianakis

Primavera odi et amo

Amo la primavera per la sua imprevedibilità e odio la primavera per la sua esuberanza (sono allergica ai pollini)

Oggi c’è un sole meraviglioso e l’aria è piena di pollini e sono ben visibili e allora basta è arrivato il momento di fare una mascherina antipollini e antismog e uscire tranquillamente (forse) 6 more words


Fueling the Mechanisms of Asthma: Increased Fatty Acid Oxidation in Inflammatory Immune Cells May Represent a Novel Therapeutic Target



Increasing evidence has shown the close link between energy metabolism and the differentiation, function, and longevity of immune cells. Chronic inflammatory conditions such as parasitic infections and cancer trigger a metabolic reprogramming from the preferential use of glucose to the up-regulation of fatty acid oxidation (FAO) in myeloid cells, including macrophages and granulocytic and monocytic myeloid-derived suppressor cells. 193 more words

By Alexandros G. Sfakianakis

Association of Japanese cedar pollinosis and sensitization with HLA-DPB1 in the Japanese adolescent

Publication date: Available online 29 April 2017
Source:Allergology International
Author(s): Wataru Morii, Aiko Sakai, Takahiro Ninomiya, Masanori Kidoguchi, Ryo Sumazaki, Shigeharu Fujieda, Emiko Noguchi
BackgroundAllergic rhinitis (AR) is a heterogeneous disorder that significantly affects daily activity, work productivity, sleep, learning, and quality of life in all generations. 217 more words

By Alexandros G. Sfakianakis

Microbes and the Role of Antibiotic Treatment for Wheezy Lower Respiratory Tract Illnesses in Preschool Children


                  </span><h3>Purpose of Review</h3> 
                  <p>Antibiotics are commonly used to treat wheezy lower respiratory tract illnesses in preschoolers, although these infections have been traditionally thought to be predominantly of viral origin. 206 more words
By Alexandros G. Sfakianakis

Granzyme B producing B-cells in renal transplant patients

Publication date: Available online 28 April 2017
Source:Clinical Immunology
Author(s): Jiqiao Zhu, Ye Zeng, Sebastian Dolff, Anja Bienholz, Monika Lindemann, Alexandra Brinkhoff, Manfred Schedlowski, Shilei Xu, Ming Sun, Hana Guberina, Julia Kirchhof, Andreas Kribben, Oliver Witzke, Benjamin Wilde… 165 more words

By Alexandros G. Sfakianakis