Tags » Arizona State University

HuffPost Morning Email: July 19th, 2017

HuffPost Morning Email: Congressional Republicans ponder next moves.

By Eliot Nelson

Wednesday, July 19

Greetings, all: Eliot Nelson here, in for Lauren Weber who, contra to our statement Tuesday, is not on a much-deserved vacation, but taking her talents to the… 598 more words

Featured

Coming soon to a broadcast near you

Last week local evening news reporter and weather anchor Kristy Siefkin visited the Memory and Attention Control Laboratory to talk with Gene Brewer about the… 34 more words

Hello, Blog

Hello, wonderful human beings of the internet! My name is Amber, and I am an incoming freshman at Arizona State University majoring in Journalism and Communications. 350 more words

Advice

We love our college students 

All Phoenix College, ASU & GCU students receive

10% off all hair services.

ASU, Arizona State University, GCU, Grand Canyon University, Phoenix College,

students, college, Phoenix, Arizona,

Salon Specials

Doing adult things; behaving like an adult

Over the past few months, I’ve accomplished a few milestones in my adult life. It still feels weird to me that I am no longer an adolescent. 180 more words

Explaining the Link Between Sleep and Alzheimer's

A new study published in brain reveals that just one night of sleep disruption causes an increase in amyloid beta in the brains of healthy, middle aged people. 1,369 more words

Neuroscience

Mr. Militant Negro reblogged this on The Militant Negro™ and commented:

Explaining the Link Between Sleep and Alzheimer’s

A new study published in brain reveals that just one night of sleep disruption causes an increase in amyloid beta in the brains of healthy, middle aged people. A full week of sleep disturbances leads to a build up of Tau, another protein associated with Alzheimer’s and other neurodegenerative diseases. The study sheds light on why poor sleep has previously been associated with the development of Alzheimer’s and other dementias. Source: Explaining the Link Between Sleep and Alzheimer’s – Neuroscience News
 
Summary: A new study published in brain reveals that just one night of sleep disruption causes an increase in amyloid beta in the brains of healthy, middle aged people. A full week of sleep disturbances leads to a build up of Tau, another protein associated with Alzheimer’s and other neurodegenerative diseases. The study sheds light on why poor sleep has previously been associated with the development of Alzheimer’s and other dementias. Source: WUSTL. Poor sleep leads to increase in Alzheimer’s proteins associated with cognitive decline. A good night’s sleep refreshes body and mind, but a poor night’s sleep can do just the opposite. A study from Washington University School of Medicine in St. Louis, Radboud University Medical Centre in the Netherlands, and Stanford University has shown that disrupting just one night of sleep in healthy, middle-aged adults causes an increase in amyloid beta, a brain protein associated with Alzheimer’s disease. And a week of tossing and turning leads to an increase in another brain protein, tau, which has been linked to brain damage in Alzheimer’s and other neurological diseases. “We showed that poor sleep is associated with higher levels of two Alzheimer’s-associated proteins,” said David M. Holtzman, MD, the Andrew B. and Gretchen P. Jones Professor, head of the Department of Neurology and the study’s senior author. “We think that perhaps chronic poor sleep during middle age may increase the risk of Alzheimer’s later in life.” These findings, published July 10 in the journal Brain, may help explain why poor sleep has been associated with the development of dementias such as Alzheimer’s. More than 5 million Americans are living with Alzheimer’s disease, which is characterized by gradual memory loss and cognitive decline. The brains of people with Alzheimer’s are dotted with plaques of amyloid beta protein and tangles of tau protein, which together cause brain tissue to atrophy and die. There are no therapies that have been proven to prevent, slow or reverse the course of the disease. Previous studies by Holtzman, co-first author Yo-El Ju, MD, an assistant professor of neurology, and others have shown that poor sleep increases the risk of cognitive problems. People with sleep apnea, for example, a condition in which people repeatedly stop breathing at night, are at risk for developing mild cognitive impairment an average of 10 years earlier than people without the sleep disorder. Mild cognitive impairment is an early warning sign for Alzheimer’s disease. But it wasn’t clear how poor sleep damages the brain. To find out, the researchers — Holtzman; Ju; co-first author and graduate student Sharon Ooms of Radboud; Jurgen Claassen, MD, PhD, of Radboud; Emmanuel Mignot, MD, PhD, of Stanford; and colleagues — studied 17 healthy adults ages 35 to 65 with no sleep problems or cognitive impairments. Each participant wore an activity monitor on the wrist for up to two weeks that measured how much time they spent sleeping each night. After five or more successive nights of wearing the monitor, each participant came to the School of Medicine to spend a night in a specially designed sleep room. The room is dark, soundproof, climate-controlled and just big enough for one; a perfect place for sleeping, even as the participants wore headphones over the ears and electrodes on the scalp to monitor brain waves. Half the participants were randomly assigned to have their sleep disrupted during the night they spent in the sleep room. Every time their brain signals settled into the slow-wave pattern characteristic of deep, dreamless sleep, the researchers sent a series of beeps through the headphones, gradually getting louder, until the participants’ slow-wave patterns dissipated and they entered shallower sleep. The next morning, the participants who had been beeped out of slow-wave sleep reported feeling tired and unrefreshed, even though they had slept just as long as usual and rarely recalled being awakened during the night. Each underwent a spinal tap so the researchers could measure the levels of amyloid beta and tau in the fluid surrounding the brain and spinal cord. A month or more later, the process was repeated, except that those who had their sleep disrupted the first time were allowed to sleep through the night undisturbed, and those who had slept uninterrupted the first time were disturbed by beeps when they began to enter slow-wave sleep. The researchers compared each participant’s amyloid beta and tau levels after the disrupted night to the levels after the uninterrupted night, and found a 10 percent increase in amyloid beta levels after a single night of interrupted sleep, but no corresponding increase in tau levels. However, participants whose activity monitors showed they had slept poorly at home for the week before the spinal tap showed a spike in levels of tau. “We were not surprised to find that tau levels didn’t budge after just one night of disrupted sleep while amyloid levels did, because amyloid levels normally change more quickly than tau levels,” Ju said. “But we could see, when the participants had several bad nights in a row at home, that their tau levels had risen.” Slow-wave sleep is the deep sleep that people need to wake up feeling rested. Sleep apnea disrupts slow-wave sleep, so people with the disorder often wake up feeling unrefreshed, even after a full eight hours of shut-eye. Slow-wave sleep is also the time when neurons rest and the brain clears away the molecular byproducts of mental activity that accumulate during the day, when the brain is busily thinking and working. Ju thinks it is unlikely that a single night or even a week of poor sleep, miserable though it may be, has much effect on overall risk of developing Alzheimer’s disease. Amyloid beta and tau levels probably go back down the next time the person has a good night’s sleep, she said.
 Image shows a print out of brain waves.

Research from Washington University School of Medicine in St. Louis, Radboud University Medical Centre in the Netherlands, and Stanford University shows that disrupting just one night of sleep in healthy, middle-aged adults causes an increase in a brain protein associated with Alzheimer’s disease. Further, a week of poor sleep leads to an increase in another brain protein that has been linked to brain damage in Alzheimer’s and other neurological diseases. Shown are brain waves during slow-wave sleep, measured as a study participant slept. NeuroscienceNews.com image is credited to Yo-El Ju.

“The main concern is people who have chronic sleep problems,” Ju said. “I think that may lead to chronically elevated amyloid levels, which animal studies have shown lead to increased risk of amyloid plaques and Alzheimer’s.” Ju emphasized that her study was not designed to determine whether sleeping more or sleeping better reduce risk of Alzheimer’s but, she said, neither can hurt. “Many, many Americans are chronically sleep-deprived, and it negatively affects their health in many ways,” Ju said. “At this point, we can’t say whether improving sleep will reduce your risk of developing Alzheimer’s. All we can really say is that bad sleep increases levels of some proteins that are associated with Alzheimer’s disease. But a good night’s sleep is something you want to be striving for anyway.”
About this neuroscience research article
Funding: Funding provided by National Institutes of Health, J.P.B Foundation, Alzheimer Nederland, Washington University Institute of Clinical and Translational Sciences, National Center for Advancing Translational Sciences. Source: Judy Martin Finch – WUSTL Image Source: NeuroscienceNews.com image is credited to Yo-El Ju. Original Research: Full open access research for “Slow wave sleep disruption increases cerebrospinal fluid amyloid-β levels” by Yo-El S. Ju, Sharon J. Ooms, Courtney Sutphen, Shannon L. Macauley, Margaret A. Zangrilli, Gina Jerome, Anne M. Fagan, Emmanuel Mignot, John M. Zempel, Jurgen A.H.R. Claassen, and David M. Holtzman in Brain. Published online July 10 2017 doi:10.1093/brain/awx148

ASU SolarSPELL Samoa Training with Peace Corps Volunteers and Local Teachers

The final highlight of the ASU SolarSPELL team’s time in Samoa was a two-day training with the Peace Corps volunteers and their local counterpart teachers. This was our team’s first opportunity to carry out a training with local teachers, and we are so grateful for the Samoa Peace Corps staff for suggesting it and then making it a reality! 629 more words