In December 1996, a group of investigators reported the results of the Fracture Intervention Trial, a randomized controlled trial that compared the effect of alendronate plus calcium or calcium supplementation alone on the risk of fractures in women who already had evidence of vertebral fractures. 806 more words
Tags » Bisphosphonates
Physicians worldwide frequently prescribe bisphosphonates such as alendronate (Fosamax) and ibandronate (Boniva) to treat osteoporosis and prevent fragility fractures. Unfortunately, long-term bisphosphonate use has been linked to an increased risk of atypical femoral fractures. 233 more words
Bisphosphonates could potentially be repurposed for the prevention and adjunctive therapy of cancer driven by human epidermal growth factor receptors, according to research published in the… 396 more words
Treatment approaches to reduce the risk of bone complications (metastasis) associated with breast cancer may be one step closer to becoming a reality.
According to a study led by a team at the Research Institute of the McGill University Health Centre (RI-MUHC), findings show that medication used to treat bone deterioration in post-menopausal women may also slow skeletal metastasis caused from breast cancer. 435 more words
A recent study in the Journal of Clinical Endocrinology & Metabolism found that approximately one out of 200 Taiwanese who used oral alendronate long term for osteoporosis developed osteonecrosis of the jaw (ONJ). 123 more words
Bisphosphonates for Complex Regional Pain Syndrome?
If you have Complex Regional Pain Syndrome and you have severe pain that has failed all remedies, you may wish to consider bisphosphonate infusions for pain relief. 1,161 more words
In recent years, several large studies involving tens of thousands of women found a potentially useful connection between bisphosphonates, the popular bone drugs, and a lower risk of breast cancer. 401 more words