Tags » Bisphosphonates


Name: Clodronate, Denusumab, Zometa, Aredia

Dosage: use as directed


Side Effects: sometimes osteonecrosis of the jaw


A German study in 1998 showed clodronate reduced metastases by 50% (in the bone only, I believe) and a… 455 more words

Filling the stone holes: my osteoporosis journey (so far)

A while back I learned I have osteoporosis.

This suuuuuuucks.

It’s not entirely unexpected — years of prednisone, weeks at a time of being ill in bed, an inability to exercise regularly and a strong genetic predisposition converged to make this more a slap I saw coming than a sucker punch. 1,165 more words


JBJS Reviews Editor’s Choice–Bisphosphonate-Related Femoral Fractures

In December 1996, a group of investigators reported the results of the Fracture Intervention Trial, a randomized controlled trial that compared the effect of alendronate plus calcium or calcium supplementation alone on the risk of fractures in women who already had evidence of vertebral fractures. 806 more words

Editor's Choice

Preventing Atypical Femoral Fractures Related to Bisphosphonates

Physicians worldwide frequently prescribe bisphosphonates such as alendronate (Fosamax) and ibandronate (Boniva) to treat osteoporosis and prevent fragility fractures. Unfortunately, long-term bisphosphonate use has been linked to an increased risk of atypical femoral fractures. 233 more words

Surgeon Edition

Bisphosphonates may hold potential for treatment, prevention of some cancers

Bisphosphonates could potentially be repurposed for the prevention and adjunctive therapy of cancer driven by human epidermal growth factor receptors, according to research published in the… 396 more words


Osteoporosis treatment may also benefit breast cancer patients

Treatment approaches to reduce the risk of bone complications (metastasis) associated with breast cancer may be one step closer to becoming a reality. 

According to a study led by a team at the Research Institute of the McGill University Health Centre (RI-MUHC), findings show that medication used to treat bone deterioration in post-menopausal women may also slow skeletal metastasis caused from breast cancer. 435 more words


Another Look at Bisphosphonates and Jaw Osteonecrosis

A recent study in the Journal of Clinical Endocrinology & Metabolism found that approximately one out of 200 Taiwanese who used oral alendronate long term for osteoporosis developed osteonecrosis of the jaw (ONJ). 123 more words

Surgeon Edition