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Rheumatic fever

What is rheumatic fever?

Rheumatic fever is an antibody mediated disease which can involve the joints, heart, brain and skin. Rheumatic fever most often manifests with low grade fever, pain and swelling of large joints – polyarthritis (knee, ankle, elbow). 193 more words

Cause Of Rheumatic Fever

What else may be as effective as tetrabenazine for chorea?

Effect of Deutetrabenazine on Chorea Among Patients With Huntington Disease: A Randomized Clinical Trial. 

Huntington Study Group

JAMA 2016; 316:40-50.

Abstract

IMPORTANCE:

Deutetrabenazine is a novel molecule containing deuterium, which attenuates CYP2D6 metabolism and increases active metabolite half-lives and may therefore lead to stable systemic exposure while preserving key pharmacological activity. 499 more words

Chorea

How do the motor features of Huntington's disease evolve with time?

Progression of motor subtypes in Huntington’s disease: a 6-year follow-up study

 Jacobs M, Hart EP, van Zwet EW, et al; REGISTRY investigators of the European Huntington’s Disease Network. 279 more words

Chorea

The Autumn Fall

I’m OK, but had a doozy of a fall today.

Not only was it a humdinger, but it was my public debut.

Ironically, it happened while I was shopping for and homing in on some sensible shoes. 567 more words

What happens when you spy on grandma

We learned that my grandmother had HD later in her life. Before then, when I was young, I spent the night at her house a lot and, from a child’s point of view, the disease manifested in two ways: she ate funny and it took her an eternity to walk. 388 more words