Tags » Gastroenterology

Adrenergic Signaling in #Muscularis Macrophages Limits Infection-Induced Neuronal Loss

..Enteric-associated neurons (EANs) are closely associated with immune cells and continuously monitor and modulate homeostatic intestinal functions, including motility and nutrient sensing. Bidirectional interactions between neuronal and immune cells are altered during disease processes such as neurodegeneration or #irritable bowel syndrome. 112 more words


T cell receptor cross-reactivity between gliadin and #bacterial peptides in #celiac disease

The human leukocyte antigen (HLA) locus is strongly associated with T cell-mediated autoimmune disorders. HLA-DQ2.5-mediated celiac disease (CeD) is triggered by the ingestion of gluten, although the relative roles of genetic and environmental risk factors in CeD is unclear. 88 more words


How do you manage C. Difficile Infections?


Q. When do you suspect a Clostridium Difficile Infection (CDI)?

  • Symptoms of unexplained and new onset ≥3 unformed stools in 24 hours plus high clinical suspicion.
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Sign Out Pearls

Investigation of persistent diarrhoea

Article from one of last year’s BJGPs, summarising the BSG guidance on investigation of persistent diarrhoea, as updated in April 2018:


Types 5 – 7 on Bristol stool chart, with increased frequency, for >4 weeks, different from normal. 498 more words


Long-term benefit of #Microbiota Transfer Therapy on #autism symptoms and gut microbiota

Many studies have reported abnormal gut microbiota in individuals with Autism Spectrum Disorders (ASD), suggesting a link between gut microbiome and autism-like behaviors. Modifying the gut microbiome is a potential route to improve gastrointestinal (GI) and behavioral symptoms in children with ASD, and fecal microbiota transplant could transform the dysbiotic gut microbiome toward a healthy one by delivering a large number of commensal microbes from a healthy donor. 97 more words


12/30 HC MTC: Acute pancreatitis

Today Dr. Malinak presented a case of acute pancreatitis due to alcohol consumption. The differential is broad in the case of this young woman with abdominal pain, nausea/vomiting, tachycardia, and hemoconcentration. 75 more words