In talks that I have given in the past few years, I have often made the point that most of genomics has not been “big data” in the usual sense, because although the raw data files can often be large, they are often processed in a more or less predictable way until they are “small” (e.g., tables of gene expression measurements or genetic variants in a small number of samples). 1,191 more words
Tags » Gene Expression
Polymorphism of IL-10 gene promoter region: association with T cell proliferative responses after acellular pertussis vaccination in adults.
Individual variation in immune responses is always encountered after vaccination. This phenomenon is also seen after acellular pertussis vaccination. The aim of this present study was to investigate whether single nucleotide polymorphisms (SNPs) in the IL-10 gene promoter region (rs1800890, rs1800896, rs1800871), IL-12B (rs2546890), IL-12RB1 (rs372889), IL-17A (rs2275913), and IL-23R (rs11209026) affect the immune responses after acellular pertussis vaccination. 178 more words
Dutch researchers from Leiden University have found that how our DNA is folded is a programmed command present in our genes, and the command varies from life-form to life-form instead of following a generic standard. 423 more words
An unprecedented molecular view of the critical early events in gene expression, a process essential for all life, has been provided by researchers at Georgia State University, the University of California at Berkeley and Northwestern University. 9 more words