Tags » Gene Expression

Current Epigenetic Perspective on Diabetes - Who Regulates the Regulators?

Samuel T. Keating (1) and Assam El-Osta (1,2,3,4)

(1) Epigenetics in Human Health and Disease Laboratory, (2) Epigenomics Profiling Facility, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precint, Melbourne, Victoria 3004, Australia. 2,393 more words

Weak control of inflammation by genes, linked to Alzheimer's development

A team of researchers from the University of Cambridge has studied data from healthy human brain tissue, revealing a signature of proteins in specific areas of the brain that could dictate vulnerability to damage in Alzheimer’s. 706 more words

Health

Mapping cell-specific histone acetylation

Changes to intracellular metabolism can alter the expression of specific histone methyltransferases and acetyltransferases conferring widespread variations in epigenetic modification patterns. Although important enzymes and chromatin changes have been described, defining the specific process governing the cell’s ability to… 255 more words

The chromatin code

The chromatin polymer is a dynamic assembly of DNA and various nuclear proteins that spatially regulates eukaryotic gene transcription by structural adaptation and genome compartmentalisation. By several distinct mechanisms, the chemical signatures of chromatin architectures are fundamental to gene expression. 1,738 more words

B. pertussis modulates human macrophage defense gene expression.

Bordetella pertussis, the etiologic agent of whooping cough, still causes outbreaks. We recently found evidence that B. pertussis can survive and even replicate inside human macrophages, indicating that this host cell might serve as a niche for persistence. 187 more words

Articles

Genomes to pathways to genes in vascular disease

Samuel T. Keating (1), Mark Ziemann (1,2), Jun Okabe (1), Aneta Balcerczyk (1), Abdul Waheed Khan (1) and Assam El-Osta (1,2,3,4).
(1) Epigenetics in Human Health and Disease Laboratory, (2) Epigenomics Profiling Facility, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precint, Melbourne, Victoria 3004, Australia. 165 more words

Context and architecture: Complexities of the genome

Most people are aware that deoxyribonucleic acid, or DNA, encodes the information that controls the development and function of all living organisms. This information is organised into regions called genes and the complement of DNA information that exists in any organism is known as its  1,467 more words