Design, Synthesis, and Pharmacological Evaluation of 5,6-Disubstituted Pyridin-2(1H)-one Derivatives as Phosphodiesterase 10A (PDE10A) Antagonists

We report the design and synthesis of novel 5,6-diarylated pyridin-2(1H)-one derivatives as pharmacophoric PDE10A inhibitors. This highly potent molecular scaffold was developed from an inactive diarylpyridine-2-amine derivative 3b by extensive and systematic analogue synthesis and SAR analysis. 268 more words

Abraham Thomas

US Delaware Court Rejects Glenmark’s Patent Plea for Bayer’s Finacea

On July 27, 2015 the District Court Of Delaware stated that Glenmark’s ANDA for generic azelaic acid hydrogel infringes Bayer’s US ‘070 patent and the claims of the US ‘070 are valid. 518 more words

Intellectual Property Rights

Delhi High Court Orders Glenmark is free to Market its Existing stock of Sitagliptin phosphate

Merk Vs Glenmark

Glenmark had launched generic version of Merck’s blockbuster anti-diabetes drug Januvia (Sitagliptin phosphate), in April 2013. Soon Merck has filed a patent infringement lawsuit against Glenmark in the Delhi high court, Delhi High Court refused to grant interim relief to Merck (plaintiff) seeking to restrain Glenmark (defendant) from launching its products Zita and Zita met. 87 more words

Delhi Highcourt