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I have been at Stage 3B PKD for almost 5 years. Approximately 5 hours after completing a month of ketoanalogue supplements, my serum creatinine had increased from 2.03 to 2.07 based on a test using the Jaffe method. I have done research on the internet in an attempt to understand whether ketoanalogues can interfere with the measurement of serum creatinine. The following is what I have been able to conclude so far. I would appreciate your specific comments and corrections to my understanding. Keto (short for ketogenic) analogues are nitrogen-free analogs of essential amino acids including certain keto acids. Certain ketone bodies, along with proteins and ascorbic acid, are known to interfere with the measurement of serum creatinine using the Jaffe method. Keto analogues contain leucine (which is solely ketogenic) and isoleucine, phenylalanine and tryptophan (which are all both ketogenic and glucogenic). Acetoacetic acid (C4H603) is a keto acid which may have a negative effect (decreased creatinine) on the measurement of serum creatinine using the Jaffe method. Acetoacetate (C4H503), which breaks down into acetone, is also a keto acid and is known to interfere (increased creatinine) with the measurement of serum creatinine using the Jaffe method. I have been unable to determine whether either acetoacetic acid or acetoacetate is contained in or produced by ketoanalogues or whether any of the above four ketone bodies contained in ketoanalogues can interfere in the measurement of serum creatinine using the Jaffe method. If there was possible interference, I plan to be re-tested using the enzymatic method. Thank you again for your help.

The Jaffe method is a colorimetric test that has many interferences and is not used much anymore. The two results that you quote are really the same number. 63 more words

Kidney-Related Health Questions