In the absence of disseminated infection such as meningitis or endocarditis, there is no convincing evidence that bacteremic pneumococcal pneumonia (BPP) requires either longer course of IV or oral antibiotics. 328 more words
Tags » Levofloxacin
When should I pay attention to the minimum inhibitory concentration (MIC) of an antibiotic despite the lab reporting it to be in the “Susceptible” range?
For most clinicians, the choice of antibiotic is based on the laboratory reporting of “Susceptible” (vs “Resistant”), not the actual MIC value of the drug. However, despite the fact that much of the data is retrospective and the association of MIC within a susceptible range and clinical outcome may not necessarily be causal, many experts recommend caution when “high” MICs within a susceptible range are observed, as found in the following situations: 310 more words
I have such mixed feelings about the FDA’s response to the November, 2015 Antimicrobial Drugs Advisory Committee meeting regarding fluoroquinolone safety. On one hand, I feel like they really did hear… 3,254 more words
Several fluoroquinolones have been removed from the market because they caused acute toxicity and death. The fluoroquinolones that have been removed from the market are not terribly different from the ones that remain on the market in terms of damage done or damage mechanisms. 2,177 more words