Tags » Medicine By Alexandros G. Sfakianakis

Superficially serrated adenoma: a proposal for a novel subtype of colorectal serrated lesion

Superficially serrated adenoma: a proposal for a novel subtype of colorectal serrated lesion

Superficially serrated adenoma: a proposal for a novel subtype of colorectal serrated lesion, Published online: 22 May 2018; … 34 more words

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Chronic Administration of Pimozide Fails to Attenuate Motor and Pathological Deficits in Two Mouse Models of Amyotrophic Lateral Sclerosis

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease which presently does not have any efficient therapeutic approach. Pimozide, a Food and Drug Administration (FDA)-approved neuroepileptic drug, has been recently proposed as a promising treatment for ALS patients based on apparent stabilization of right hand muscles after a short-time administration. 213 more words

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Construct validity and reliability of the Finnish version of the Knee Injury and Osteoarthritis Outcome Score

Abstract


Background

The Knee Injury and Osteoarthritis Outcome Score (KOOS) is a commonly used knee assessment and outcome tool in both clinical work and research. However, it has not been formally translated and validated in Finnish. 280 more words

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Precise detection of de novo single nucleotide variants in human genomes [Genetics]

The precise determination of de novo genetic variants has enormous implications across different fields of biology and medicine, particularly personalized medicine. Currently, de novo variations are identified by mapping sample reads from a parent–offspring trio to a reference genome, allowing for a certain degree of differences. 19 more words

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Reducing resistance allele formation in CRISPR gene drive [Genetics]

CRISPR homing gene drives can convert heterozygous cells with one copy of the drive allele into homozygotes, thereby enabling super-Mendelian inheritance. Such a mechanism could be used, for example, to rapidly disseminate a genetic payload in a population, promising effective strategies for the control of vector-borne diseases. 19 more words

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Suppressor mutation analysis combined with 3D modeling explains cohesin’s capacity to hold and release DNA [Genetics]

Cohesin is a fundamental protein complex that holds sister chromatids together. Separase protease cleaves a cohesin subunit Rad21/SCC1, causing the release of cohesin from DNA to allow chromosome segregation. 37 more words

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GSE94824 Super-enhancer Driven Core Regulatory Circuitry in MYCN-amplified Neuroblastoma

Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Other ; Expression profiling by array
Organism : Homo sapiens

This SuperSeries is composed of the SubSeries listed below. 15 more words

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