Tags » Medicine By Alexandros G. Sfakianakis

Visualization of endothelial cell cycle dynamics in mouse using the Flt-1/eGFP-anillin system

Abstract

Endothelial cell proliferation is a key process during vascular growth but its kinetics could only be assessed in vitro or ex vivo so far. To enable the monitoring and quantification of cell cycle kinetics in vivo, we have generated transgenic mice expressing an eGFP-anillin construct under control of the endothelial-specific Flt-1 promoter. 129 more words

Medicine By Alexandros G. Sfakianakis

Association between systemic leptin and neurotensin concentration in adult individuals with and without type 2 diabetes mellitus

Abstract


Purpose

Leptin is an adipokine which regulates appetite and energy balance through a mechanism partially mediated by neurotensin (NT) in central nervous system. Besides acting as a neurotransmitter, NT is expressed in human intestine where it promotes fat absorption and its circulating levels associate with obesity, type 2 diabetes mellitus (T2DM) and cardiovascular disease. 216 more words

Medicine By Alexandros G. Sfakianakis

A novel role of the corticotropin-releasing hormone (CRH) regulating peptide, teneurin-1 C-terminal associated peptide (TCAP-1), on glucose uptake into the brain

Abstract

Teneurin C-terminal associated peptide (TCAP) is an ancient paracrine signaling agent that evolved via lateral gene transfer from prokaryotes into an early metazoan ancestor. Although it bears structural similarity to corticotropin-releasing hormone (CRH), it inhibits the… 237 more words

Medicine By Alexandros G. Sfakianakis

Characterization of active and infiltrative tumorous subregions from normal tissue in brain gliomas using multiparametric MRI

Background

Targeted localized biopsies and treatments for diffuse gliomas rely on accurate identification of tissue subregions, for which current MRI techniques lack specificity.

Purpose

To explore the complementary and competitive roles of a variety of conventional and quantitative MRI methods for distinguishing subregions of brain gliomas. 277 more words

Medicine By Alexandros G. Sfakianakis

Histogram analysis of stretched-exponential and monoexponential diffusion-weighted imaging models for distinguishing low and intermediate/high gleason scores in prostate carcinoma

Background

Noninvasive measures to evaluate the aggressiveness of prostate carcinoma (PCa) may benefit patients.

Purpose

To assess the value of stretched-exponential and monoexponential diffusion-weighted imaging (DWI) for predicting the aggressiveness of PCa. 253 more words

Medicine By Alexandros G. Sfakianakis

Ultramorphological Characteristics of Podocyte Development in the Human Fetal Metanephros

The aim of this study was to determine the developmental characteristics of podocytes in the human fetal metanephros using scanning electron microscopy, light microscopy, and transmission electron microscopy. 229 more words

Medicine By Alexandros G. Sfakianakis