Tags » Neurobiochemistry

Milestone: The X-ray Crystal structure of the voltage gated sodium channel

The crystal structure of a voltage-gated sodium channel

Jian Payandeh, Todd Scheuer, Ning Zheng & William A. Catterall

Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA… 248 more words


Combining Crystallography and Physical Chemistry (FRET) to study the conformations of fast excitatory AMPA receptors

FRET = single-molecule fluorescence resonance energy transfer

Structural landscape of isolated agonist-binding domains from single AMPA receptors

Christy F Landes, Anu Rambhadran, J Nick Taylor, Ferandre Salatan & Vasanthi Jayaraman… 153 more words


Cognition enhancement strategies

Cognition enhancement strategies.

J Neurosci. 2010 Nov 10;30(45):14987-92.
Bibb JA, Mayford MR, Tsien JZ, Alberini CM.
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. 151 more words


α-Synuclein protein advances Parkinson's by preventing neurons from clearing debris

α-Synuclein impairs macroautophagy: implications for Parkinson’s disease

JCB Home > 2010 Archive > 20 September > Winslow et al. 190 (6): 1023

Ashley R. Winslow1, Chien-Wen Chen1,3, Silvia Corrochano4, Abraham Acevedo-Arozena4, David E. 172 more words


Molecular Basis of Plasticity: SynCAM 1 Adhesion Dynamically Regulates Synapse Number and Impacts Plasticity and Learning

Neurons that fire together wire together.
Adhesion molecule SynCAM1: promotes new synapses in the developing brain, holds synaptic junctions together, and impacts the maintenance and function of these structure.
369 more words


Axon and target communicate to organize synaptic differentiation.

Key Presynaptic organizers: NT-7a, neuroligin, synaptic cell adhesion molecule (SynCAM) and fibroblast growth factor-22 (FGF-22) have all been identified as target-derived presynaptic organizers
Key Postsynaptic organizers: 241 more words


Neurogenesis in the adult human hippocampus

Neurogenesis in the adult human hippocampus

Nature Medicine 4, 1313 – 1317 (1998)
Peter S. Eriksson1, 4, Ekaterina Perfilieva1, Thomas Björk-Eriksson2, Ann-Marie Alborn1, Claes Nordborg3, Daniel A. 187 more words