Tags » NMDA

Cocktail Time

Everyone loves a cocktail, right? I know I do. Here’s what goes into my favourite cocktail of the moment. Prednisolone, Levetiracetam, Azathioprine, AdCal D3, Omeprazole and Venlafaxine XL. 521 more words


Further Ramblings

I have a huge respect for anyone who decides to follow a path into any medical profession. From the ground up these are the people who keep us ticking over until the next mystery illness comes along. 774 more words


Ramblings of a Mad Man

In an effort to clear my head I have taken to writing a few thoughts down. It might help those close to me to understand why I’m such a miserable bastard and why I’ve lost my mojo. 528 more words


What are the treatment options for refractory autoimmune encephalitis?

 Tocilizumab in autoimmune encephalitis refractory to rituximab: an institutional cohort study

Lee WJ, Lee ST, Moon J, et al.

Neurotherapeutics 2016; 13:824-832.


A considerable portion of autoimmune encephalitis (AE) does not respond to conventional immunotherapies and subsequently has poor outcomes. 254 more words


Conceptualizing Autoimmune & Paraneoplastic Limbic Encephalitis

Paraneoplastic and Autoimmune Encephalitis refers to a heterogeneous group of neurologic conditions whereby autoantibody formation disrupts normal neuronal and neurologic function. Because of their relatively recent discovery (basically last 20 years), more and more cases are being recognized in the clinical setting, and more and more patients are being suspected of having “autoimmune encephalitis.” However, I would caution any provider against considering autoimmune or paraneoplastic encephalitis in the differential diagnosis of a patient with unexplained altered mental status. 538 more words


Magnesium: a versatile drug for anesthesiologists

From: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726845/

MOA: multiple including blockade of nmda and Calcium channels

Magnesium has multiple advantages including:


Reversal of evoked gamma oscillation deficits is predictive of antipsychotic activity with a unique profile for clozapine. (2016)

Reversal of evoked gamma oscillation deficits is predictive of antipsychotic activity with a unique profile for clozapine.

Recent heuristic models of schizophrenia propose that abnormalities in the gamma frequency cerebral oscillations may be closely tied to the pathophysiology of the disorder, with hypofunction of N-methyl-d-aspartate receptors (NMDAr) implicated as having a crucial role. 248 more words