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Conceptualizing Autoimmune & Paraneoplastic Limbic Encephalitis

Paraneoplastic and Autoimmune Encephalitis refers to a heterogeneous group of neurologic conditions whereby autoantibody formation disrupts normal neuronal and neurologic function. Because of their relatively recent discovery (basically last 20 years), more and more cases are being recognized in the clinical setting, and more and more patients are being suspected of having “autoimmune encephalitis.” However, I would caution any provider against considering autoimmune or paraneoplastic encephalitis in the differential diagnosis of a patient with unexplained altered mental status. 538 more words

Neuroimmunology

Magnesium: a versatile drug for anesthesiologists

From: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726845/

MOA: multiple including blockade of nmda and Calcium channels

Magnesium has multiple advantages including:

Intra-op

Reversal of evoked gamma oscillation deficits is predictive of antipsychotic activity with a unique profile for clozapine. (2016)

Reversal of evoked gamma oscillation deficits is predictive of antipsychotic activity with a unique profile for clozapine.

Recent heuristic models of schizophrenia propose that abnormalities in the gamma frequency cerebral oscillations may be closely tied to the pathophysiology of the disorder, with hypofunction of N-methyl-d-aspartate receptors (NMDAr) implicated as having a crucial role. 248 more words

Schizophrenia

Remembering is everything

Remembrance Sunday is a day when we remember. We remember those that lost their lives fighting for a better Britain. We remember the everyday heroes that fought for our country, both on the battlefields and back at home. 499 more words

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