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Oral vitamin B1-substitution does not decrease genetically determined cleft rate in mice (A/WySn)

Cleft lip and palate (CL/P) are one of the most common human birth defects. Animal experiments and clinical investigations show a clear reduction of teratogenic clefts by a high-dose vitamin B supplementation during early pregnancy, especially in families at risk (reduction of recurrence). 34 more words

By Alexandros G. Sfakianakis

Additive effect of radiosensitization by 2-deoxy-D-glucose delays DNA repair kinetics and suppresses cell proliferation in oral squamous cell carcinoma

Abstract

Background

It has well known that, compared to normal cells, tumor cells have a different manner of energy metabolism, which influences the sensitivity of radiotherapy (RT). 226 more words

By Alexandros G. Sfakianakis

High level βIII-tubulin overexpression occurs in most head and neck cancers but is unrelated to clinical outcome

Abstract

Background

βIII-tubulin (TUBB3) is an isotype of microtubules, which are involved in crucial cellular roles including maintenance of cell shape, intracellular transport, and mitosis. Overexpression of TUBB3 was found to be associated with poor prognosis and resistance to tubulin-binding drugs and in several solid tumors including head and neck squamous cell carcinomas (HNSCC). 148 more words

By Alexandros G. Sfakianakis