Tags » Stem Cell

Saskatoon celebrates second annual Clara's Day at the Park

Watch above: Clara’s Day at the Park celebrates the lives of Rafaela and Clara Andrade. As Jackie Wilson reports, it is a way for friends and family to give back to the community. 398 more words


Researchers identify new architecture and mechanism in the human sperm.

In male fertility normal sperm cells have an oval-shaped head with a cap-like covering called the acrosome. The acrosome contains enzymes that break down the outer membrane of an egg cell, allowing the sperm to fertilize the egg. 486 more words


The Isl1/Ldb1 Complex Orchestrates Genome-wide Chromatin Organization to Instruct Differentiation of Multipotent Cardiac Progenitors

Bhaskar Chanda Stem Cell Caputo et al. identify Ldb1 as a crucial regulator of cardiogenesis. Ldb1 binds the key cardiac transcription factor Isl1 and protects it from degradation. 36 more words


Genome-wide RNA-Seq of Human Motor Neurons Implicates Selective ER Stress Activation in Spinal Muscular Atrophy

Bhaskar Chanda Stem Cell Loss of the protein SMN causes spinal muscular atrophy, but it is unclear why deficiency in the ubiquitously expressed protein primarily affects motor neurons. 35 more words


Aberrant Lipid Metabolism in the Forebrain Niche Suppresses Adult Neural Stem Cell Proliferation in an Animal Model of Alzheimer’s Disease

Bhaskar Chanda Stem Cell Hamilton et al. identify deregulation of niche fatty acid metabolism as a mechanism of disease-induced stem cell impairment. They show that interfering with oleic acid signaling or synthesis rescues NSC proliferation in a mouse model of Alzheimer’s, revealing a potential approach to promote NSC-mediated brain function and repair. 13 more words


Rho-Signaling-Directed YAP/TAZ Activity Underlies the Long-Term Survival and Expansion of Human Embryonic Stem Cells

Bhaskar Chanda Stem Cell Ohgushi et al. show that a regulatory pathway involving Rho, YAP/TAZ, and the actin cytoskeleton that is specific for the pluripotent state enables human embryonic stem cells to undergo long-term survival and expansion in culture. 13 more words

Stem Cell

Humanized Mice Reveal Differential Immunogenicity of Cells Derived from Autologous Induced Pluripotent Stem Cells

Bhaskar Chanda Stem Cell Patient iPSCs have potential as a renewable source for autologous cell therapy that avoids immune rejection. Using a humanized mouse model with a functional human immune system, Zhao et al. 33 more words