Tags » Stem Cell
Pharmacological Reprogramming of Fibroblasts into Neural Stem Cells by Signaling-Directed Transcriptional Activation
Bhaskar Chanda Stem Cell Zhang et al. identified a cocktail of nine components that can efficiently reprogram defined mouse fibroblasts into tripotent neural stem cell-like cells and revealed that this reprogramming process involves transcriptional activation of key neurogenic regulators downstream of reprogramming signaling. 13 more words
Genome Editing of Lineage Determinants in Human Pluripotent Stem Cells Reveals Mechanisms of Pancreatic Development and Diabetes
Bhaskar Chanda Stem Cell By combining genome editing and hPSC-directed differentiation, Zhu and colleagues systematically examined eight transcription factors for their roles in pancreatic development. Their study not only verified conserved gene requirements between mice and humans but also revealed a number of previously unsuspected and potentially human-specific features. 13 more words
Bhaskar Chanda Stem Cell Chen et al. show that motor function in PD mice can be reversed or enhanced following transplantation of dopamine neurons differentiated from hPSCs engineered to express DREADDs. 35 more words
DETROIT (WWJ) – Three million people in this country are living with epilepsy. Now there’s a new way to help in their treatment.
One way many people control their seizures is through medication. 157 more words