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Ground State Conditions Induce Rapid Reorganization of Core Pluripotency Factor Binding before Global Epigenetic Reprogramming

Bhaskar Chanda Stem Cell Meissner and colleagues provide a comprehensive characterization of the early OCT4, SOX2, and NANOG binding dynamics during the transition from serum/LIF to 2i. 46 more words

Stem Cell

Single-Cell Transcriptomics Reveals a Population of Dormant Neural Stem Cells that Become Activated upon Brain Injury

Bhaskar Chanda Stem Cell Llorens-Bobadilla et al. perform single-cell RNA sequencing of acutely isolated neural stem cells (NSCs) from the adult SVZ, identifying lineage-primed NSCs residing along a continuum of co-existing states between dormancy and activation. 30 more words

Stem Cell

These Cells Are What People Died For

Ladies and gentlemen. I present to you…the wha…? Does anyone know what the bloody devil that is?
For some strange and magical reason, that tiny little speck of carbohydrates, protein, lipids, and nucleic acids is the source of all the misery and death of countless human beings. 148 more words

Opinions

Functional Correction of Large Factor VIII Gene Chromosomal Inversions in Hemophilia A Patient-Derived iPSCs Using CRISPR-Cas9

Bhaskar Chanda Stem Cell Park et al. used CRISPR-Cas9 in patient iPSCs to correct two large inversions that are the most common underlying mutations for severe hemophilia, and they show that the correction is functional by rescuing lethality in hemophiliac mice using iPSC-derived endothelial cells. 12 more words

Stem Cell

Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia

Bhaskar Chanda Stem Cell Reya and colleagues identify Tetraspanin 3 as a key signal required for AML. Tspan3 deletion leads to improved survival in mouse models of AML and reduced cancer growth in xenografts. 33 more words

Stem Cell

Random thought 1

I was at church trying to listen to the sermon (or not) when this thought came to mind: a New-born Christian is like a stem cell.

Global Stem Cell Therapy Market Future Outlook

Stem cells are specialized cells that can differentiate into other cells without losing their identity. They have been found to be present in animals as well as humans and most of the work has been done on mice. 1,242 more words

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