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My stem cell experience   When I was fifteen years old, forty years ago, I tore the meniscus in my left knee playing basketball. Back in the 70s, arthroscopic surgery was not an available option. The only way to go was under the knife and have the surgeon remove as much of the loose meniscus cartilage as he could. I ended up getting eighteen stitches accompanied with many weeks of recovery and therapy. Fifteen years after, I tore the meniscus in my right knee playing the same sport. Talk about bad luck. I was sidelined from my beloved sport. Fortunately, scope surgery became a standard procedure for knee injury interventions. I ended up with just the three small holes on my knee and the downtime was only about two weeks. Now, 38 years later, at 53, my left knee has chronic pain due to bone on bone contact. I went to a PT and they informed me that I have a knee susceptible to arthritis. She showed me some exercises but it didn’t relieve any pain. I went to an ortho clinic to try the visc gel shots but the pain relief only lasted two weeks. The same doctor gave me a couple of cortisone shots but the relief was short-lived as well. After all, when you’re bone on bone, there really isn’t anything that can relieve the pain except…knee replacement surgery. Two years have gone by and my knee is getting worse, I needed help. My quality of life has gone down significantly. After shopping around for doctors, I decided to go with one of the best surgeons in the knee replacement industry. Two weeks before my surgery, I received a phone call from my doctor’s office and told me that my doctor had an accident and wouldn’t be able to walk for six months. She apologized and gave me the option to pick another doctor for same surgery date. Anxious to get it done, I met with the other doctor and he said he needs to cancel the surgery until further notice because of a tooth infection that my dentist has discovered. Got to be 80% healthy before going under the knife! About a week later, a friend of mine mentioned stem cell treatments. She said her chiropractor believes in it and highly recommends it. That night started weeks of sleepless nights googling, researching, blogging everything about stem cell for the knee. Regenexx kept popping up and I started to find out that they are the most advanced and most reputable of all sites and reviews in my research. Most importantly, I didn’t see one bad review or a bad comment about Regenexx. I realized that stem cell treatment for the knee has so many good and promising results that I decided to cancel my surgery and go with the stem cell treatment. I can’t wait! My first visit to HealthLink Regenexx was mid-July 2016. The doctor told me that the MRI showed bone on bone on the lateral side (outer side) of my left knee. He then used an ultrasound to further and survey my condition. The spacing between the bones is very narrow and my knee is not very stable. He said I am not a good, nor a poor candidate, but a fair one. I said let’s go for it… I was then advised to have my insurance prescribe an unloader brace. An expensive brace indeed ,$800, but nonetheless, a brace I should’ve been wearing all this time had I known about it. My consult appointment cost about $300. I bought some supplements from the clinic to build up on stem cell count for before and after the treatment. I was told my treatments would be a total of three days scheduled to start on Monday, August 15, 2016. First day of treatment finally came, called Prolotherapy. The doctor gave a total of almost ten injections to my knee. It’s supposed to cause micro injury to the joint area to aggravate the knee, so blood supply would rush to it and start the healing process. The human body is amazing. My knee was very sore that night, but the next morning - it felt fantastic! My next treatment is tomorrow, Wednesday the 17th. The big day is here. The day my own stem cells get injected into my knee. My wife and I arrived 8:30 am. My finger got pricked for a hemoglobin test and reflected good results. The surgery is a go. I went into the next room where I had to lay down on my stomach with a padded face support much like getting a massage. But today is no massage. I waited for about twenty minutes. The doctor arrived, numbed my lower back area before he can start drilling and extracting my stem cells from the bone marrow in my hip. There wasn’t any major pain, but I felt a little pinch here and there and there was a lot pressure on my hips; the doctor had to put a little force and some weight into the drilling process. Next thing I knew, it was done. Just like that huh? They told me to be back in about an hour and a half while they process my stem cell so the doctor can inject it into my knee. At 11 am, as I lay on my back with my knee propped up on a padded wedge, the doctor came in and was amazed by the results of how high my stem cell count is. He said my count is almost 900 million where the average they’ve had is 500 million. This will really help in the healing and repairing process. Our prayers and taking the recommended supplements definitely helped. Since my stem cell count is really good, the doctor took advantage of it by injecting more to cover more areas of my knee. He gave my knee a total of ten stem cell shots with the bone on bone target problem area getting about three or four. I have to say that those shots gave me considerable amount of pain and excruciating at times. But I kept thinking while doing my deep breathing, that this is the worst part of the treatment and it’s almost over…nothing worth-while comes too easy. It was finally over. I was asked to lie there for about a half hour so the stem cell can settle down and start working in my knee. I asked the doctor how Friday is going to be. He said it’ll be an easy one. Just a blood-draw and a couple of soothing shots to my knee. We arrived 8:30 am, Friday the 19th , for the final treatment. Just what the doctor said, two or three vials of blood were drawn out from me and was told to come back in two hours while they process my blood. Two hours later, went into a smaller room where the doctor noticed I have some swelling on the knee. Before using ultrasound and administering the PRP (platelet-rich plasma) shots, he had to drain out the fluid from my inflammation with a syringe. Oh boy, here we go again, the pain reminded me of the Wednesday’s shots. I didn’t expect that coming. The PRP shots started and I didn’t feel any pain at all. I guess these final shots act like fertilizer to assist in the repair and growth of cartilage. It’s finally over and I am very satisfied. It’s been a week now and I can already feel my knee is healing. Best part is – I’m not so bed-ridden. I am still taking the supplements and I wear my brace except when showering and sleeping. I am also using the Thermotex heating pad twice a day. I am supposed to take it easy for the first seven to ten days with minimal walking. After that, I gradually go back to normal activities week after week. I will try to post updates every week or so. Until next time, stay healthy!

Knee Replacement Alternative

Zika Virus Infects Neural Progenitors in the Adult Mouse Brain and Alters Proliferation

Bhaskar Chanda Stem Cell Li et al. show that peripheral ZIKV exposure in a mouse model can infect adult neural stem cells in the brain, leading to cell death and reduced proliferation. 30 more words

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Zika Virus Infects Neural Progenitors in the Adult Mouse Brain and Alters Proliferation

Bhaskar Chanda Stem Cell Li et al. show that peripheral ZIKV exposure in a mouse model can infect adult neural stem cells in the brain, leading to cell death and reduced proliferation. 30 more words

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Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro

Bhaskar Chanda Stem Cell hiPSC-CM transcriptome profiling showed greater inter-patient than intra-patient variation. Toxicology analysis predicted and functionally validated individualized drug responsiveness, suggesting that hiPSC-CMs could serve as preclinical readout platforms for precision medicine. 13 more words

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Multipotency of Adult Hippocampal NSCs In Vivo Is Restricted by Drosha/NFIB

Bhaskar Chanda Stem Cell Rolando et al. investigated the function of the RNaseIII Drosha in the regulation of adult hippocampal stem cell maintenance and differentiation. They found that Drosha directly inhibits the expression of the transcription factor NFIB through a miRNA-independent mechanism, thereby permitting neurogenesis and preventing oligodendrocyte fate commitment. 12 more words

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Enhancing a Wnt-Telomere Feedback Loop Restores Intestinal Stem Cell Function in a Human Organotypic Model of Dyskeratosis Congenita

Bhaskar Chanda Stem Cell Using a human induced pluripotent stem cell-derived dyskeratosis congenita (DC) organotypic model, Woo and colleagues show that telomere shortening triggers abrogation of canonical Wnt signaling, resulting in defects in intestinal stem cell function. 30 more words

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How Stem Cells are Made

In 2014, the scientific community was shaken. Haruko Obokata, a Japanese researcher at a highly respected Japanese Government research institution published a controversial scientific research paper in one of the most highly respected and highly recognized scientific journal–Nature.Her research theme?An easy method to “make” stem cells.  328 more words

Regenerative Medicine,