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Neurogenic Radial Glia-like Cells in Meninges Migrate and Differentiate into Functionally Integrated Neurons in the Neonatal Cortex

Bhaskar Chanda Stem Cell Carmeliet and colleagues have identified a population of radial glia-like neural progenitor cells located in the meninges of postnatal mice. After birth, these cells migrate through the caudal ventricular zone and then differentiate into functional and integrated neurons of the posterior cortex. 12 more words

Stem Cell

Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition

Bhaskar Chanda Stem Cell Latil and colleagues show that tumor phenotypes and propensity for EMT are dictated by cell-type-specific chomatin and transcriptional states of the cancer cell of origin. 33 more words

Stem Cell

The p53 Family Coordinates Wnt and Nodal Inputs in Mesendodermal Differentiation of Embryonic Stem Cells

Bhaskar Chanda Stem Cell Massagué and colleagues show that the p53/63/73 family is essential for mesendoderm specification in embryonic stem cells. The p53 family transcriptionally activates the Wnt pathway in human and mouse ESCs to coordinate Wnt-Tcf and nodal-Smad inputs for mesendodermal differentiation of ESCs in vitro and in the embryo. 12 more words

Stem Cell

DNA Methylation Dynamics of Human Hematopoietic Stem Cell Differentiation

Bhaskar Chanda Stem Cell As part of the IHEC consortium, Bock and colleagues present genome-wide reference maps of DNA methylation dynamics during human blood development. The characteristic DNA methylation patterns they see in the different cell types allow data-driven inference of an epigenome-based model of hematopoietic differentiation. 22 more words

Stem Cell

Cardiac Fibroblasts Adopt Osteogenic Fates and Can Be Targeted to Attenuate Pathological Heart Calcification

Bhaskar Chanda Stem Cell Pillai et al. demonstrate that cardiac fibroblasts adopt bone-forming cell fates and induce ectopic calcification. ENPP1, an enzyme that regulates bone mineralization, is induced in cardiac fibroblasts after injury. 30 more words

Stem Cell

Two-Way Conversion between Lipogenic and Myogenic Fibroblastic Phenotypes Marks the Progression and Resolution of Lung Fibrosis

Bhaskar Chanda Stem Cell El Agha et al. use genetic engineering in mice to identify precursor cells for activated myofibroblasts and investigate their fate in a reversible model of lung fibrosis. 35 more words

Stem Cell

Conversion of Terminally Committed Hepatocytes to Culturable Bipotent Progenitor Cells with Regenerative Capacity

Bhaskar Chanda Stem Cell Katsuda et al. report reprogramming of mature hepatocytes into expandable bipotent progenitors, CLiPs, using small molecules. CLiPs substantially repopulate injured mouse livers, suggesting the potential clinical application of this approach. 19 more words

Stem Cell