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Stage-Specific Human Induced Pluripotent Stem Cells Map the Progression of Myeloid Transformation to Transplantable Leukemia

Bhaskar Chanda Stem Cell Kotini et al. integrate patient cell reprogramming with mutational analysis to assemble a panel of iPSCs capturing distinct stages across the spectrum of myeloid malignancy. 38 more words

Stem Cell

Cholinergic Signals from the CNS Regulate G-CSF-Mediated HSC Mobilization from Bone Marrow via a Glucocorticoid Signaling Relay

Bhaskar Chanda Stem Cell Pierce et al. show that the muscarinic receptor type-1 (Chrm1) expression in the brain regulates HSC mobilization from bone marrow via the hypothalamic-pituitary-adrenal axis, leading to glucocorticoid-mediated control of actin organization pathways. 12 more words


Genome Editing in hPSCs Reveals Haploinsufficiency and a Genetic Interaction with in Human Pancreatic Development

Bhaskar Chanda Stem Cell Huangfu, Chen, and colleagues model human pancreatic disease by stepwise differentiation of genetically modified hPSCs to characterize the phenotypic effects of GATA6 haploinsufficiency not evident in mouse models and its genetic interaction with GATA4. 12 more words


Nicotinamide Ameliorates Disease Phenotypes in a Human iPSC Model of Age-Related Macular Degeneration

Bhaskar Chanda Stem Cell Saini et al. show that hiPSC-derived RPE, including ARMS2/HTRA1 homozygotes, from AMD patients exhibit higher complement and inflammatory factors compared to healthy controls. 37 more words


Human iPSC-Derived Neural Progenitors Are an Effective Drug Discovery Model for Neurological mtDNA Disorders

Bhaskar Chanda Stem Cell Prigione and colleagues show that neural progenitors differentiated from patient-derived iPSCs are an effective modeling tool for neuronal disease associated with mtDNA mutations and can be used for drug screening. 14 more words


Recent Zika Virus Isolates Induce Premature Differentiation of Neural Progenitors in Human Brain Organoids

Bhaskar Chanda Stem Cell Gabriel and colleagues show that two recently isolated Zika strains efficiently infect neural progenitors in human brain organoids and cause premature differentiation in a way that closely resembles Zika-associated microcephaly and differs from the effects seen with an older and extensively passaged strain. 14 more words


Human iPSC-Derived Cerebral Organoids Model Cellular Features of Lissencephaly and Reveal Prolonged Mitosis of Outer Radial Glia

Bhaskar Chanda Stem Cell Bershteyn and colleagues show that cerebral organoid modeling of lissencephaly using iPSCs derived from Miller-Dieker syndrome patients can characterize cellular and neurodevelopmental disease phenotypes and identify a mitotic defect in outer radial glia, a cell type that is particularly important for human cortical development. 12 more words