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Human iPSC-Derived Cerebral Organoids Model Cellular Features of Lissencephaly and Reveal Prolonged Mitosis of Outer Radial Glia

Bhaskar Chanda Stem Cell Bershteyn and colleagues show that cerebral organoid modeling of lissencephaly using iPSCs derived from Miller-Dieker syndrome patients can characterize cellular and neurodevelopmental disease phenotypes and identify a mitotic defect in outer radial glia, a cell type that is particularly important for human cortical development. 12 more words

Stem Cell

Pericytes of Multiple Organs Do Not Behave as Mesenchymal Stem Cells In Vivo

Bhaskar Chanda Stem Cell Guimarães-Camboa et al. permanently labeled pericytes and vascular smooth muscle of multiple organs in vivo and followed the fate of these cells in aging and injury models. 36 more words


RNA Helicase DDX5 Inhibits Reprogramming to Pluripotency by miRNA-Based Repression of RYBP and its PRC1-Dependent and -Independent Functions

Bhaskar Chanda Stem Cell RNA-binding proteins have poorly defined roles in somatic cell reprogramming. Li et al. show that the RNA-binding protein DDX5 erects an epigenetic barrier to reprogramming. 39 more words


"We Are Creatures of Consequence"

Earlier this week I had the privilege of spending the day in the labs of the Krembil Discovery Tower at Toronto Western Hospital run by some of our country’s top researchers in the fields of Osteoarthritis and Alzheimers disease.   462 more words

Glioblastoma Cancer Stem Cells Evade Innate Immune Suppression of Self-Renewal through Reduced TLR4 Expression

Bhaskar Chanda Stem Cell Alvarado et al. demonstrate that glioblastoma cancer stem cells express a lower level of the innate immune receptor TLR4 than surrounding cells, which allows them to avoid inhibitory innate immune signaling that would otherwise suppress self-renewal. 12 more words

Stem Cell

Immunosuppression via Loss of IL2rγ Enhances Long-Term Functional Integration of hESC-Derived Photoreceptors in the Mouse Retina

Bhaskar Chanda Stem Cell Lamba and colleagues show that immunosuppression can significantly improve the survival and functional integration of hESC-derived cells into recipient mouse retinas as far out as 9 months, suggesting that immunosuppression may be a useful way to enhance clinical cell transplantation outcomes for patients even in a location traditionally considered immune-privileged. 12 more words

Stem Cell

Human AML-iPSCs Reacquire Leukemic Properties after Differentiation and Model Clonal Variation of Disease

Bhaskar Chanda Stem Cell Chao et al. show that MLL-rearranged AML patient cells can be reprogrammed into induced pluripotent stem cells (iPSCs). These cells reacquire leukemic properties and associated methylation/gene expression patterns after hematopoietic differentiation and provide a means to study the differential properties of specific disease subclones. 12 more words

Stem Cell