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Quantitative Dynamics of Chromatin Remodeling during Germ Cell Specification from Mouse Embryonic Stem Cells

Bhaskar Chanda Stem Cell Kurimoto et al. perform careful analyses of chromatin remodeling during mouse germ cell specification from embryonic stem cells. Widespread epigenetic reprogramming events included re-organization of H3K27me3 and bivalent signatures as well as progressive deletion of H3K9me2 throughout the genome, creating a unique foundation for the epigenome of the next generation. 12 more words


The Long Noncoding RNA Regulates Neuronal Differentiation of Embryonic and Postnatal Neural Stem Cells

Bhaskar Chanda Stem Cell Ramos et al. describe Pinky (Pnky), a neural-specific lncRNA that localizes to the nucleus of neural stem cells (NSCs). Pnky knockdown in NSCs increases neurogenesis. 38 more words


Long Non-Coding RNAs Control Hematopoietic Stem Cell Function

Bhaskar Chanda Stem Cell Luo et al. perform deep RNA sequencing of hematopoietic stem cells (HSCs), identifying previously unannotated long non-coding RNAs (lncRNAs) enriched in this cell population. 37 more words


Lymphoid Regeneration from Gene-Corrected SCID-X1 Subject-Derived iPSCs

Bhaskar Chanda Stem Cell Menon, Firth, and colleagues show that TALEN-mediated correction of a novel splice site mutation in the IL-2Rγ gene rescues defective development of mature NK cells from iPSCs derived from a SCID-X1 subject. 28 more words


Elucidating Molecular Phenotypes Caused by the SORL1 Alzheimer’s Disease Genetic Risk Factor Using Human Induced Pluripotent Stem Cells

Bhaskar Chanda Stem Cell Development of late-onset, sporadic Alzheimer’s disease (SAD) has been linked with a range of genetic loci, but determining how variants within these loci contribute to disease progression remains challenging. 47 more words


Is Academic Research a Dead Man Walking?

On March 4, 2015 at 1pm ET (timezone converter), #hcsmca will be co-hosted by OpenLab (@UHNOpenLab), a design and innovation shop dedicated to finding creative solutions that transform the way health care is delivered and experienced, and the…

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Successful Function of Autologous iPSC-Derived Dopamine Neurons following Transplantation in a Non-Human Primate Model of Parkinson’s Disease

Bhaskar Chanda Stem Cell A pre-clinical test of transplantation of autologous iPSC-derived dopamine neurons in a cynomolgus monkey model of Parkinson’s disease provides proof of principle for long-term innervation and functional benefit without a requirement for immunosuppression. 13 more words