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Naive Human Pluripotent Cells Feature a Methylation Landscape Devoid of Blastocyst or Germline Memory

Bhaskar Chanda Stem Cell Pastor and colleagues show that reversion of primed hESCs in 5iLAF, or derivation of hESCs in 5iLAF, results in a population of naive cells characterized by loss of the marker SSEA4. 30 more words

Stem Cell

Why this year’s flu season is off to a slow, nearly non-existent start

While health officials had their hands full in 2014-15 with a nasty H3N2 flu season, Canadians have managed to stave off influenza so far this year. 902 more words

News

Bile Acids Protect Expanding Hematopoietic Stem Cells from Unfolded Protein Stress in Fetal Liver

Bhaskar Chanda Stem Cell Sigurdsson et al. report that bile acids unexpectedly function as chemical chaperones that are critically required for alleviating ER stress during expansion of fetal hematopoietic stem cells. 12 more words

Stem Cell

Replacement of Lost Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters

Bhaskar Chanda Stem Cell In this article, Tetteh et al. show that enterocyte-lineage progenitors can become stem cells during intestinal regeneration. Additionally, these cells generate Paneth-like cells and turn on genes that promote recovery from injury. 34 more words

Stem Cell

Is ‘man flu’ real? Canadian docs explain sex differences in fighting the flu

He’s depicted as lying in bed, covered in used tissues, cough syrup and self pity. The flu is infamous for bringing a grown man to his knees. 869 more words

Health

Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming

Bhaskar Chanda Stem Cell By imaging cell fate conversion over time, Gascón, Murenu, and colleagues find that high levels of oxidative stress prevent successful direct neuronal reprogramming, instead causing extensive cell death. 41 more words

Scientist

Stepwise Clearance of Repressive Roadblocks Drives Cardiac Induction in Human ESCs

Bhaskar Chanda Stem Cell In this article, Greber and colleagues reveal signaling principles that underlie directed differentiation of human ESCs into cardiomyocytes. The authors show that BMP and WNT pathways promote cardiac induction through sequential and dose-dependent suppression of repressive regulators that otherwise drive differentiation into alternate lineages. 12 more words

Scientist