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MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis

Bhaskar Chanda Stem Cell Aranda-Orgilles et al. show in vivo a cell-autonomous requirement of MED12 in the maintenance of hematopoietic stem cell function independent of CYCLIN C/CDK8. 41 more words

Stem Cell

RNA Splicing Modulation Selectively Impairs Leukemia Stem Cell Maintenance in Secondary Human AML

Bhaskar Chanda Stem Cell Crews et al. show that unique splice isoform signatures distinguish normal human HSC and progenitor cell aging from AML and MDS progenitors. 44 more words

Stem Cell

3D Culture Supports Long-Term Expansion of Mouse and Human Nephrogenic Progenitors

Bhaskar Chanda Stem Cell Li et al. report the derivation and long-term culture of mouse and human nephron progenitor cell lines under chemically defined conditions in 3D format. 36 more words

Stem Cell

Zika Virus Infects Neural Progenitors in the Adult Mouse Brain and Alters Proliferation

Bhaskar Chanda Stem Cell Li et al. show that peripheral ZIKV exposure in a mouse model can infect adult neural stem cells in the brain, leading to cell death and reduced proliferation. 30 more words

Stem Cell

Zika Virus Infects Neural Progenitors in the Adult Mouse Brain and Alters Proliferation

Bhaskar Chanda Stem Cell Li et al. show that peripheral ZIKV exposure in a mouse model can infect adult neural stem cells in the brain, leading to cell death and reduced proliferation. 30 more words

Stem Cell

Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro

Bhaskar Chanda Stem Cell hiPSC-CM transcriptome profiling showed greater inter-patient than intra-patient variation. Toxicology analysis predicted and functionally validated individualized drug responsiveness, suggesting that hiPSC-CMs could serve as preclinical readout platforms for precision medicine. 13 more words

Stem Cell

Multipotency of Adult Hippocampal NSCs In Vivo Is Restricted by Drosha/NFIB

Bhaskar Chanda Stem Cell Rolando et al. investigated the function of the RNaseIII Drosha in the regulation of adult hippocampal stem cell maintenance and differentiation. They found that Drosha directly inhibits the expression of the transcription factor NFIB through a miRNA-independent mechanism, thereby permitting neurogenesis and preventing oligodendrocyte fate commitment. 12 more words

Stem Cell