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Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation

Bhaskar Chanda Stem Cell Przybyla et al. describe how properties of the extracellular matrix can direct fate specification in hESCs. They show that mechanical forces resulting from differential matrix stiffness translate via junctional organization, Src, and β-catenin into transcriptional responses that drive mesodermal differentiation. 13 more words

Stem Cell

Molecular Obstacles to Clinical Translation of iPSCs

Bhaskar Chanda Stem Cell Several studies have suggested that some iPSC clones display tumorigenic and immunogenic potential as well as variations in their differentiation potential, thus raising concerns about their utility and safety in the clinical setting. 31 more words

Stem Cell

Age-Dependent Niche Signals from the Choroid Plexus Regulate Adult Neural Stem Cells

Bhaskar Chanda Stem Cell Silva-Vargas et al. show that the lateral ventricle choroid plexus is a novel niche component for adult V-SVZ neural stem cells and their progeny and exhibits dynamic changes with aging. 13 more words

Stem Cell

Conversion of Human Gastric Epithelial Cells to Multipotent Endodermal Progenitors using Defined Small Molecules

Bhaskar Chanda Stem Cell Wang et al. show that a set of defined small molecules plus mesenchymal feeder cells can covert human gastric epithelial cells into induced endodermal progenitors with multilineage differentiation capacity. 34 more words

Scientist

Molecular Criteria for Defining the Naive Human Pluripotent State

Bhaskar Chanda Stem Cell Theunissen et al. use molecular criteria based on transposon expression, DNA methylation, and X chromosome status to compare naive human pluripotent cells to human preimplantation embryos. 25 more words

Stem Cell

Ectopic miR-125a Expression Induces Long-Term Repopulating Stem Cell Capacity in Mouse and Human Hematopoietic Progenitors

Bhaskar Chanda Stem Cell Wojtowicz et al. report that enforced expression of miR-125a confers enhanced long-term self-renewal potential to multipotent hematopoietic progenitors (MPPs). Quantitative proteomics reveals a miR-125a target network that normally functions to restrain self-renewal in more committed progenitors. 26 more words

Stem Cell

The Central Nervous System Regulates Embryonic HSPC Production via Stress-Responsive Glucocorticoid Receptor Signaling

Bhaskar Chanda Stem Cell In this study, North and colleagues uncover serotonin-stimulated central regulation of hematopoietic stem cell production during embryonic development, mediated by the stress-responsive hypothalamic-pituitary-adrenal/interrenal (HPA/I) axis and glucocorticoid receptor. 34 more words

Stem Cell