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The Locus Preserves LT-HSC Function by Inhibiting the PI3K-mTOR Pathway to Restrict Mitochondrial Metabolism

Bhaskar Chanda Stem Cell Qian and colleagues show that ncRNAs expressed from the imprinted locus Dlk1-Gtl2 maintain fetal liver and adult LT-HSCs through multiplexed inhibition of PI3K-mTOR signaling that in turn keeps mitochondrial biogenesis and metabolic activity in check. 13 more words

Stem Cell

Cancer Diary Series

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Hope you are all fantabulous!

I have been suffering from a nasty cold, you know the kind where just when you think you are on the road to good health, WHAM, the next day you feel worse. 362 more words

Cancer Journey

Functional Connectivity under Optogenetic Control Allows Modeling of Human Neuromuscular Disease

Bhaskar Chanda Stem Cell Steinbeck and colleagues use optogenetics in human spinal motorneurons to establish a functional neuromuscular junction with co-cultured skeletal muscle in vitro and then apply this system for phenotypic analysis of an autoimmune disease. 13 more words

Stem Cell

Phosphorylation of eIF2α Is a Translational Control Mechanism Regulating Muscle Stem Cell Quiescence and Self-Renewal

Bhaskar Chanda Stem Cell Adult stem cells require regulated protein synthesis. Crist and colleagues show that translational control by eIF2α regulates the activity of the skeletal muscle stem cell. 33 more words

Stem Cell

Histone Demethylase Expression Enhances Human Somatic Cell Nuclear Transfer Efficiency and Promotes Derivation of Pluripotent Stem Cells

Bhaskar Chanda Stem Cell Zhang and colleagues show that, as they found previously in mouse, injection of a histone demethylase improves the efficiency of human SCNT reprogramming. 39 more words


Polycomb Complex PRC1 Preserves Intestinal Stem Cell Identity by Sustaining Wnt/β-Catenin Transcriptional Activity

Bhaskar Chanda Stem Cell Chiacchiera et al. show that PRC1 activity is essential to maintain integrity of the intestinal epithelium during homeostasis and in cancer. Mechanistically, PRC1 represses non-lineage-specific transcription factors that in turn directly affect β-catenin/Tcf transcriptional activity and Wnt-dependent intestinal stem cell self-renewal. 13 more words


Coordination of mA mRNA Methylation and Gene Transcription by ZFP217 Regulates Pluripotency and Reprogramming

Bhaskar Chanda Stem Cell Aguillo et al. show that ZFP217 coordinates epigenetic and epitranscriptomic networks to control embryonic stem cell pluripotency and somatic cell reprogramming. ZFP217 directly activates core stem cell genes and restrains m6A deposition in their transcripts through interaction with METTL3, coupling transcription and mRNA methylation to control stemness. 13 more words