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Successful Function of Autologous iPSC-Derived Dopamine Neurons following Transplantation in a Non-Human Primate Model of Parkinson’s Disease

Bhaskar Chanda Stem Cell A pre-clinical test of transplantation of autologous iPSC-derived dopamine neurons in a cynomolgus monkey model of Parkinson’s disease provides proof of principle for long-term innervation and functional benefit without a requirement for immunosuppression. 13 more words


CDK6 Levels Regulate Quiescence Exit in Human Hematopoietic Stem Cells

Bhaskar Chanda Stem Cell The hematopoietic stem cell (HSC) compartment is heterogeneous in terms of cell cycle properties. Laurenti et al. show that the timing of exit from quiescence in human HSC subsets is controlled by CDK6 expression levels. 26 more words


mA RNA Methylation Is Regulated by MicroRNAs and Promotes Reprogramming to Pluripotency

Bhaskar Chanda Stem Cell Zhou and colleagues show that formation of m6A on mRNAs is regulated by miRNAs via a sequence pairing mechanism, and that in addition to differential distribution in pluripotent and differentiated cells, m6A has a positive influence on reprogramming to pluripotency. 13 more words


Why is measles so contagious? 5 things you need to know

WATCH ABOVE: What makes the measles so contagious?

TORONTO – There’s the runny nose, sore throat, red eyes and the trademark rash of red dots. A measles outbreak is slowly growing in Toronto where health officials… 963 more words


Ascl2 Acts as an R-spondin/Wnt-Responsive Switch to Control Stemness in Intestinal Crypts

Bhaskar Chanda Stem Cell The Wnt signaling pathway controls stem cell identity in the intestinal epithelium, but it has remained unclear how the continuous Wnt gradient is translated into discrete cell type specification. 33 more words


The NAD-Dependent SIRT1 Deacetylase Translates a Metabolic Switch into Regulatory Epigenetics in Skeletal Muscle Stem Cells

Bhaskar Chanda Stem Cell Connecting metabolic cues to stem cell activity via epigenetic regulation: Sartorelli and colleagues show that during activation, satellite cells undergo a metabolic switch that leads to decreased intracellular NAD+, reduced SIRT1 deacetylase activity, elevated H4K16 acetylation, and an increase in muscle-related gene expression. 14 more words