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A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis

Bhaskar Chanda Stem Cell Fujii et al. generated a comprehensive organoid library from colorectal cancer patients. Each organoid line was characterized by gene expression and as xenografts recapitulating the original clinical phenotype. 45 more words

Stem Cell

Genetic Drift Can Compromise Mitochondrial Replacement by Nuclear Transfer in Human Oocytes

Bhaskar Chanda Stem Cell Yamada et al. show, using human cells, that even small amounts of mtDNA carried over during nuclear transfer for mitochondrial replacement can lead to mtDNA genotype reversion. 28 more words

Stem Cell

Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation

Bhaskar Chanda Stem Cell Dominguez-Brauer et al. show that the ubiquitin ligase Mule fine-tunes the Wnt pathway via c-Myc to control unwarranted proliferation and stem cell expansion. 35 more words

Stem Cell

Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice

Bhaskar Chanda Stem Cell The suspected link between Zika virus (ZIKV) infection and microcephaly has raised urgent global alarm. However, there is so far no direct evidence for ZIKV infection impacting brain development. 55 more words

Stem Cell

Zika Virus Depletes Neural Progenitors in Human Cerebral Organoids through Activation of the Innate Immune Receptor TLR3

Bhaskar Chanda Stem Cell Dang et al. show that Zika virus (ZIKV) attenuates growth in cerebral organoids from human embryonic stem cells by targeting neural progenitors. 38 more words

Stem Cell

Pharmacological Reprogramming of Fibroblasts into Neural Stem Cells by Signaling-Directed Transcriptional Activation

Bhaskar Chanda Stem Cell Zhang et al. identified a cocktail of nine components that can efficiently reprogram defined mouse fibroblasts into tripotent neural stem cell-like cells and revealed that this reprogramming process involves transcriptional activation of key neurogenic regulators downstream of reprogramming signaling. 13 more words

Scientist

Genome Editing of Lineage Determinants in Human Pluripotent Stem Cells Reveals Mechanisms of Pancreatic Development and Diabetes

Bhaskar Chanda Stem Cell By combining genome editing and hPSC-directed differentiation, Zhu and colleagues systematically examined eight transcription factors for their roles in pancreatic development. Their study not only verified conserved gene requirements between mice and humans but also revealed a number of previously unsuspected and potentially human-specific features. 13 more words

Stem Cell