Tags » UHN

Pharmacological Reprogramming of Fibroblasts into Neural Stem Cells by Signaling-Directed Transcriptional Activation

Bhaskar Chanda Stem Cell Zhang et al. identified a cocktail of nine components that can efficiently reprogram defined mouse fibroblasts into tripotent neural stem cell-like cells and revealed that this reprogramming process involves transcriptional activation of key neurogenic regulators downstream of reprogramming signaling. 13 more words

Stem Cell

Genome Editing of Lineage Determinants in Human Pluripotent Stem Cells Reveals Mechanisms of Pancreatic Development and Diabetes

Bhaskar Chanda Stem Cell By combining genome editing and hPSC-directed differentiation, Zhu and colleagues systematically examined eight transcription factors for their roles in pancreatic development. Their study not only verified conserved gene requirements between mice and humans but also revealed a number of previously unsuspected and potentially human-specific features. 13 more words

Stem Cell

Chemical Control of Grafted Human PSC-Derived Neurons in a Mouse Model of Parkinson’s Disease

Bhaskar Chanda Stem Cell Chen et al. show that motor function in PD mice can be reversed or enhanced following transplantation of dopamine neurons differentiated from hPSCs engineered to express DREADDs. 35 more words

Scientist

Canadian study suggests the term 'palliative care' needs rebranding

TORONTO – A widespread perception of palliative care as being synonymous with death is preventing many patients from accessing supportive therapies aimed at improving their quality of life, researchers say. 863 more words

Health

Identification and Correction of Mechanisms Underlying Inherited Blindness in Human iPSC-Derived Optic Cups

Bhaskar Chanda Stem Cell Parfitt et al. derived human 3D optic cup organoids to model LCA, a retinal dystrophy associated with aberrant CEP290 splicing leading to cilia defects. 40 more words

Stem Cell

Activation of Endogenous Retroviruses in ESCs Involves Disruption of SETDB1-Mediated Repression by NP95 Binding to Hemimethylated DNA

Bhaskar Chanda Stem Cell Sharif et al. show that transient derepression of proviral loci following acute depletion of Dnmt1 in ESCs is not dependent on loss of DNA methylation per se. 39 more words

Stem Cell

Age-Related Accumulation of Somatic Mitochondrial DNA Mutations in Adult-Derived Human iPSCs

Bhaskar Chanda Stem Cell Mitalipov, Huang, and colleagues show that human iPSCs derived from older adults carry more mitochondrial DNA mutations than those derived from younger individuals. 33 more words

Stem Cell