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The Isl1/Ldb1 Complex Orchestrates Genome-wide Chromatin Organization to Instruct Differentiation of Multipotent Cardiac Progenitors

Bhaskar Chanda Stem Cell Caputo et al. identify Ldb1 as a crucial regulator of cardiogenesis. Ldb1 binds the key cardiac transcription factor Isl1 and protects it from degradation. 36 more words

Stem Cell

Genome-wide RNA-Seq of Human Motor Neurons Implicates Selective ER Stress Activation in Spinal Muscular Atrophy

Bhaskar Chanda Stem Cell Loss of the protein SMN causes spinal muscular atrophy, but it is unclear why deficiency in the ubiquitously expressed protein primarily affects motor neurons. 35 more words

Stem Cell

Aberrant Lipid Metabolism in the Forebrain Niche Suppresses Adult Neural Stem Cell Proliferation in an Animal Model of Alzheimer’s Disease

Bhaskar Chanda Stem Cell Hamilton et al. identify deregulation of niche fatty acid metabolism as a mechanism of disease-induced stem cell impairment. They show that interfering with oleic acid signaling or synthesis rescues NSC proliferation in a mouse model of Alzheimer’s, revealing a potential approach to promote NSC-mediated brain function and repair. 13 more words

Stem Cell

Rho-Signaling-Directed YAP/TAZ Activity Underlies the Long-Term Survival and Expansion of Human Embryonic Stem Cells

Bhaskar Chanda Stem Cell Ohgushi et al. show that a regulatory pathway involving Rho, YAP/TAZ, and the actin cytoskeleton that is specific for the pluripotent state enables human embryonic stem cells to undergo long-term survival and expansion in culture. 13 more words

Stem Cell

Humanized Mice Reveal Differential Immunogenicity of Cells Derived from Autologous Induced Pluripotent Stem Cells

Bhaskar Chanda Stem Cell Patient iPSCs have potential as a renewable source for autologous cell therapy that avoids immune rejection. Using a humanized mouse model with a functional human immune system, Zhao et al. 33 more words

Stem Cell

Single-Cell RNA-Seq with Waterfall Reveals Molecular Cascades underlying Adult Neurogenesis

Bhaskar Chanda Stem Cell In vivo molecular dynamics of adult stem cells have been elusive. Shin et al. used single-cell RNA-seq and a novel bioinformatic approach named Waterfall to reconstruct somatic stem cell dynamics with unprecedented temporal resolution. 26 more words

Stem Cell

Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors

Bhaskar Chanda Stem Cell Haas et al. show that inflammatory signaling activates post-transcriptional protein synthesis, maturation, and cell cycle induction in quiescent, but primed, stem-like megakaryocyte progenitors. 24 more words

Stem Cell